College of Nursing, Sungshin University, Seoul, Korea.
Department of Energy Resources Engineering, Seoul National University, Seoul, Korea.
Geriatr Gerontol Int. 2017 Nov;17(11):2136-2142. doi: 10.1111/ggi.13049. Epub 2017 May 16.
The aim of the present study was to evaluate the age-specific prevalence of dementia, and develop a metabolic risk indicator for dementia according to sex.
This cross-sectional study was carried out from September 2007 through December 2012 with 19 935 elderly participants in metropolitan Seoul, Korea. Multiphase assessments were used to measure metabolic risk factors and confirm dementia according to sex. Specifically, multivariate logistic regression analyses were used to identify how elderly men and women differed in regard to metabolic risk indicators of dementia.
The adjusted prevalence rates of dementia in elderly Seoul residents were estimated at 4.9%, 6.1% and 5.6% in men, women and the overall population, respectively. Stroke conferred an odds ratio of 5.14 (95% CI 3.91-6.77) and 2.55 (95% CI 2.01-3.25) in men and women, respectively. Additionally, within the female population, diabetes mellitus conferred an odds ratio of 1.29 (95% CI 1.09-1.53), whereas alcohol consumption conferred an odds ratio of 0.77 (95% CI 0.61-0.97).
Stroke played a primary role as a metabolic risk indicator of dementia in elderly men, while diabetes mellitus and alcohol abstinence were important metabolic risk factors in elderly women. Taken together, the data show that when designing preventative measures against dementia based on metabolic risk, sex needs to be taken into account. Geriatr Gerontol Int 2017; 17: 2136-2142.
本研究旨在评估特定年龄段人群的痴呆患病率，并根据性别制定针对痴呆的代谢风险指标。
本横断面研究于 2007 年 9 月至 2012 年 12 月在韩国首尔大都市进行，共纳入 19935 名老年参与者。采用多阶段评估测量代谢危险因素，并根据性别确定痴呆。具体而言，采用多变量逻辑回归分析确定男性和女性在痴呆的代谢风险指标方面有何差异。
调整后的首尔老年居民痴呆患病率分别为男性 4.9%、女性 6.1%和总体人群 5.6%。在男性和女性中，卒中的比值比分别为 5.14（95%CI 3.91-6.77）和 2.55（95%CI 2.01-3.25）。此外，在女性人群中，糖尿病的比值比为 1.29（95%CI 1.09-1.53），而饮酒的比值比为 0.77（95%CI 0.61-0.97）。
卒中在男性中是痴呆的主要代谢风险指标，而糖尿病和戒酒在女性中是重要的代谢风险因素。总之，这些数据表明，在基于代谢风险制定预防痴呆的措施时，需要考虑性别因素。老年医学与老年病学杂志 2017；17：2136-2142。
