苯并菲啶生物碱与DNA相互作用的生物物理方面及生物学意义。
Biophysical aspects and biological implications of the interaction of benzophenanthridine alkaloids with DNA.
作者信息
Maiti Motilal, Kumar Gopinatha Suresh
机构信息
Biophysical Chemistry Laboratory, Indian Institute of Chemical Biology, Kolkata, 700032, India.
出版信息
Biophys Rev. 2009 Sep;1(3):119-129. doi: 10.1007/s12551-009-0014-7. Epub 2009 Aug 25.
Abstract
Benzophenanthridine alkaloids represent a very interesting and significant group of natural products that exhibit a broad range of biological and pharmacological properties. Among this group of alkaloids, sanguinarine, nitidine, fagaronine, and chelerythrine have the potential to form molecular complexes with DNA structures and have attracted recent attention for their possible clinical and pharmacological utility. This review focuses on the interaction of these alkaloids with polymorphic DNA structures (B-form, Z-form, H-form, and triple helical form) reported by several research groups employing various physical techniques such as spectrophotometry, spectrofluorimetry, circular dichroism, NMR spectroscopy, thermal melting, viscometry as well as thermodynamic analysis by isothermal titration calorimetry and differential scanning calorimetry to elucidate the mode and mechanism of action at the molecular level to determine the structure-activity relationship. DNA binding properties of these alkaloids are interpreted in relation to their biological activity.
摘要
苯并菲啶生物碱是一类非常有趣且重要的天然产物，具有广泛的生物学和药理学特性。在这类生物碱中，血根碱、白屈菜红碱、去甲斑蝥素和白屈菜赤碱有可能与DNA结构形成分子复合物，并且因其潜在的临床和药理用途而受到了近期的关注。本综述聚焦于几个研究小组利用多种物理技术（如分光光度法、荧光光谱法、圆二色光谱法、核磁共振光谱法、热变性、粘度测定法以及通过等温滴定量热法和差示扫描量热法进行的热力学分析）所报道的这些生物碱与多态性DNA结构（B型、Z型、H型和三螺旋型）之间的相互作用，以阐明其在分子水平上的作用方式和机制，从而确定结构 - 活性关系。这些生物碱的DNA结合特性与其生物学活性相关联进行解释。
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