天然异喹啉生物碱：与功能蛋白、血清白蛋白、血红蛋白和溶菌酶的结合情况
Natural isoquinoline alkaloids: binding aspects to functional proteins, serum albumins, hemoglobin, and lysozyme.
作者信息
Khan Asma Yasmeen, Suresh Kumar Gopinatha
机构信息
Biophysical Chemistry Laboratory, Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, 700 032, India.
出版信息
Biophys Rev. 2015 Dec;7(4):407-420. doi: 10.1007/s12551-015-0183-5. Epub 2015 Nov 16.
Abstract
The putative anticancer alkaloids berberine, palmatine, jatrorrhizine, and sanguinarine are known to bind to nucleic acids. To develop them as potential drugs for therapeutic use, their binding affinity to functional proteins and mode of transport in the circulatory system need to be clearly understood. Towards this, many studies on their binding aspects to proteins have been reported and a considerable amount of data, mostly of biophysical nature, exists in the literature. The importance of these natural isoquinoline alkaloids and the recent literature on their interaction phenomena with functional proteins, serum albumins, hemoglobin, and lysozyme are presented in this review.
摘要
已知假定的抗癌生物碱黄连素、巴马汀、药根碱和血根碱可与核酸结合。为了将它们开发成潜在的治疗药物，需要清楚地了解它们与功能蛋白的结合亲和力以及在循环系统中的运输方式。为此，已经报道了许多关于它们与蛋白质结合方面的研究，并且文献中存在大量主要是生物物理性质的数据。本文综述了这些天然异喹啉生物碱的重要性以及最近关于它们与功能蛋白、血清白蛋白、血红蛋白和溶菌酶相互作用现象的文献。
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