中国 HIV 感染者抗逆转录病毒治疗药物依从性的影响因素：ART 相关知识的调节作用。
Influence of Side Effects on ART Adherence Among PLWH in China: The Moderator Role of ART-Related Knowledge.
机构信息
Department of Health Promotion, Education, and Behavior & South Carolina SmartState Center for Healthcare Quality (CHQ), University of South Carolina Arnold School of Public Health, 915 Greene Street, Columbia, SC, 29208, USA.
School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, People's Republic of China.
出版信息
AIDS Behav. 2018 Mar;22(3):961-970. doi: 10.1007/s10461-017-1791-9.
Despite the medical advancements in HIV treatment, realities of side effects are faced by people living with HIV (PLWH) who receive antiretroviral therapy (ART). Mixed findings have been reported on the association between side effects and ART adherence. However, few studies have explored the combined side effects and behavior-related information on medication adherence. The aim of the current study is to examine moderator role of ART-related knowledge between side effects and ART adherence. A cross-sectional survey was conducted among 2987 PLWH from October 2012 to August 2013 in China. Of the total sample, 2095 patients had received ART and provided ART adherence. Side effects, ART-related knowledge, and ART adherence, as well as potential covariates were assessed. The results revealed that there was a negative relationship of side effects and ART adherence existed among low and medium levels of ART-related knowledge, but not among high level of knowledge. Future interventions to promote HIV medication adherence should focus on providing behavior-related information education among PLWH.
尽管在 HIV 治疗方面取得了医学进步，但接受抗逆转录病毒疗法 (ART) 的 HIV 感染者 (PLWH) 仍面临着副作用的现实。关于副作用与 ART 依从性之间的关联，已有混合的研究结果报告。然而，很少有研究探讨药物依从性的副作用和行为相关信息的综合情况。本研究旨在检验 ART 相关知识在副作用与 ART 依从性之间的调节作用。2012 年 10 月至 2013 年 8 月期间，在中国对 2987 名 PLWH 进行了横断面调查。在总样本中，有 2095 名患者接受了 ART 并提供了 ART 依从性数据。评估了副作用、ART 相关知识和 ART 依从性以及潜在的协变量。结果表明，在 ART 相关知识水平较低和中等的情况下，副作用与 ART 依从性之间存在负相关，但在知识水平较高的情况下则不存在。未来促进 HIV 药物依从性的干预措施应侧重于为 PLWH 提供行为相关信息教育。
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