Cvitanović Hrvoje, Šitum Mirna, Meštrović-Štefekov Jelena, Lugović-Mihić Liborija
Hrvoje Cvitanović, MD, MSc, Department of Dermatovenereology, Karlovac General Hospital, A. Štampara 3, 47000 Karlovac, Croatia;
Acta Dermatovenerol Croat. 2017 Apr;25(1):32-38.
Stressful life events in response to a psychosocial trigger have been reported to negatively affect the course of infections. This study was based on patients with clinical manifestations of human papillomavirus (HPV) infection and a control group of patients with psoriasis who were admitted over a period of one year to the Dermatology Department of Karlovac General Hospital. A total of 122 patients participated in the study, either with a confirmed diagnosis of clinical manifestations of HPV infection (n=66) or in a psoriasis control group (n=56). The aim of this study was to determine which coping strategies are used in patients with clinical manifestations of HPV infection. We used the Recent Life Changes Questionnaire and Brief COPE test for stress evaluation. There were no statically significant differences between adaptive and maladaptive coping strategies comparing patients with HPV and a control group. The difference in specific coping strategies between HPV and control groups showed that self-blame and planning strategies were statistically significantly more common in the HPV group. Patients with HPV with genital warts used maladaptive coping statistically significantly more than patients with non-genital localization of HPV. Patients with HPV who had a higher score of life stress events used maladaptive coping statistically significantly more than patients with a lower life stress events score. The results point to the need for patients with HPV with genital localization and high numbers of stress events to learn how to cope with stress, enabling them to take action and change their ways of coping. There is also a need to integrate psychological intervention into standard care protocols of dermatologic diseases.
据报道，因心理社会触发因素而产生的压力性生活事件会对感染病程产生负面影响。本研究以出现人乳头瘤病毒（HPV）感染临床表现的患者为基础，并设立了一个银屑病患者对照组，这些患者在一年时间里被收治于卡尔洛瓦茨综合医院皮肤科。共有122名患者参与了该研究，其中确诊有HPV感染临床表现的患者有66名，银屑病对照组有56名。本研究的目的是确定出现HPV感染临床表现的患者会采用哪些应对策略。我们使用近期生活变化问卷和简易应对方式问卷来评估压力。在比较HPV患者和对照组时，适应性和适应不良应对策略之间没有统计学上的显著差异。HPV组和对照组在特定应对策略上的差异表明，自责和计划策略在HPV组中在统计学上显著更为常见。患有尖锐湿疣的HPV患者在统计学上比HPV非生殖器部位患者更多地采用适应不良应对方式。生活压力事件得分较高的HPV患者在统计学上比生活压力事件得分较低的患者更多地采用适应不良应对方式。结果表明，患有生殖器部位HPV且压力事件较多的患者需要学习如何应对压力，使他们能够采取行动并改变应对方式。还需要将心理干预纳入皮肤病标准护理方案中。
