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[非血红素铁的低分子量和蛋白质二亚硝基配合物作为血小板聚集抑制剂]

[Low molecular weight and protein dinitrosyl complexes of non-heme iron as inhibitors of platelet aggregation].

作者信息

Kuznetsov V A, Mordvintsev P I, Dank E Kh, Iurkiv V A, Vanin A F

出版信息

Vopr Med Khim. 1988 Sep-Oct;34(5):43-6.

PMID:2851211
Abstract

Dinitrosyl complexes of ferrum with thiosulfate or reduced glutathione were found to inhibit completely aggregation of human thrombocytes, suspended in artificial protein-free medium. The inhibitory effect appears to occur as a result of activating action of nitrogen oxide derived from the complexes and affecting the thrombocyte guanylate cyclase.

摘要

已发现铁与硫代硫酸盐或还原型谷胱甘肽形成的二亚硝酰配合物能完全抑制悬浮于无蛋白人工培养基中的人血小板聚集。这种抑制作用似乎是由于配合物衍生的一氧化氮的激活作用以及对血小板鸟苷酸环化酶的影响而产生的。

相似文献

1
[Low molecular weight and protein dinitrosyl complexes of non-heme iron as inhibitors of platelet aggregation].[非血红素铁的低分子量和蛋白质二亚硝基配合物作为血小板聚集抑制剂]
Vopr Med Khim. 1988 Sep-Oct;34(5):43-6.
2
[Inhibition of platelet aggregation by dinitrosyl iron complexes with low molecular weight ligands].[低分子量配体二亚硝基铁配合物对血小板聚集的抑制作用]
Biokhimiia. 1986 Nov;51(11):1851-7.
3
Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation.S-亚硝基硫醇对人血小板聚集的抑制作用。血红素依赖性可溶性鸟苷酸环化酶的激活及环磷酸鸟苷积累的刺激作用。
Mol Pharmacol. 1983 May;23(3):653-64.
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Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione.S-亚硝基谷胱甘肽抗血小板作用中不依赖环鸟苷酸机制的证据。
Br J Pharmacol. 1998 May;124(1):141-8. doi: 10.1038/sj.bjp.0701821.
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[Effect of exogenous donors of nitric oxide and inhibitors of its enzymatic synthesis on experimental ischemic thrombosis in conjunctive veins of the rabbit eyes].[外源性一氧化氮供体及其酶促合成抑制剂对兔眼结膜静脉实验性缺血性血栓形成的影响]
Biofizika. 2008 Mar-Apr;53(2):315-25.
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Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase.CORM-3释放的一氧化碳通过一种独立于可溶性鸟苷酸环化酶的机制抑制人类血小板。
Cardiovasc Res. 2006 Jul 15;71(2):393-401. doi: 10.1016/j.cardiores.2006.03.011. Epub 2006 Mar 22.
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[Soluble platelet guanylate cyclase: significance of heme in regulating enzymatic activity and the role of the enzyme in platelet aggregation].
Biokhimiia. 1994 Mar;59(3):325-39.
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Relaxin depresses platelet aggregation: in vitro studies on isolated human and rabbit platelets.松弛素可抑制血小板聚集：对分离出的人及兔血小板的体外研究。
Lab Invest. 1995 Nov;73(5):709-16.
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Effect of dinitrosyl iron complexes on platelet aggregation induced by HeLa cervical carcinoma cells.
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The released proteins from avian thrombocytes.来自禽类血小板释放的蛋白质。
Thromb Haemost. 1979 Dec 21;42(4):1289-95.

引用本文的文献

1
Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity.二亚硝酰铁配合物的物理化学性质作为其生物活性的决定因素
Int J Mol Sci. 2021 Sep 26;22(19):10356. doi: 10.3390/ijms221910356.
2
Synthetic methodology for preparation of dinitrosyl iron complexes.用于制备亚硝酰铁配合物的合成方法学。
J Biol Inorg Chem. 2019 Jun;24(4):495-515. doi: 10.1007/s00775-019-01668-z. Epub 2019 May 20.