Magazanik L G
Zh Evol Biokhim Fiziol. 1988 Sep-Oct;24(5):657-67.
Factors which control the duration of postsynaptic responses in neuromuscular junctions are discussed together with a possibility of origin of trace postsynaptic reactions (potentiation and desensitization). In experiments on nerve-muscle preparations of various vertebrates (lamprey, frog, chicken, rat), the key role of functional activity of acetylcholinesterase was revealed in regulation of the duration of both short- and long-living postsynaptic responses. The significance of sufficient activity of acetylcholinesterase for normal realization of neuromuscular transmission presumably increases in the course of evolution of vertebrates. An analysis of possible molecular nature of trace reactions on the postsynaptic membrane was carried out.
讨论了控制神经肌肉接头处突触后反应持续时间的因素，以及微量突触后反应（增强和脱敏）的起源可能性。在对各种脊椎动物（七鳃鳗、青蛙、鸡、大鼠）的神经肌肉标本进行的实验中，乙酰胆碱酯酶的功能活性在调节短寿命和长寿命突触后反应的持续时间方面发挥了关键作用。乙酰胆碱酯酶足够的活性对于神经肌肉传递正常实现的重要性可能在脊椎动物进化过程中增加。对突触后膜上微量反应可能的分子性质进行了分析。
