Iwamuro Masaya, Kobayashi Sayo, Ohara Nobuya, Kawano Seiji, Kawahara Yoshiro, Okada Hiroyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Case Rep Gastrointest Med. 2017;2017:7916976. doi: 10.1155/2017/7916976. Epub 2017 Apr 23.
An 86-year-old Japanese man was presented to our hospital for further investigation of duodenal adenocarcinoma. The tumor was endoscopically resected. Pathological analysis revealed coexistence of gastric foveolar metaplasia and a surrounding hyperplastic Brunner's gland, in addition to an adenocarcinoma component. Immunostaining for MUC5AC and MUC6 confirmed the diagnosis of adenocarcinoma in situ arising from Brunner's gland hyperplasia. This case suggests that although detailed preoperative evaluation is required to determine the depth of tumor invasion, endoscopic resection may be a promising option for the treatment of adenocarcinomas arising from Brunner's gland hyperplasia.
一名86岁的日本男性因十二指肠腺癌进一步检查而入住我院。肿瘤通过内镜切除。病理分析显示，除腺癌成分外，还存在胃小凹化生和周围增生的Brunner腺。MUC5AC和MUC6免疫染色证实了Brunner腺增生原位腺癌的诊断。该病例表明，尽管需要详细的术前评估以确定肿瘤浸润深度，但内镜切除可能是治疗Brunner腺增生引起的腺癌的一个有前景的选择。
