Department of Immunology, Changzhi Medical College, Changzhi, Shanxi 046000, China.
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Biomed Res Int. 2017;2017:1584658. doi: 10.1155/2017/1584658. Epub 2017 Apr 20.
. Slowly growing mycobacteria (SGM) are prevalent worldwide and cause an extensive spectrum of diseases. . In this study, the antimicrobial susceptibility of 33 reference strains of SGM to 19 antimicrobial agents was tested using a modified microdilution method. . Cefmetazole (32/33) and azithromycin (32/33) exhibited the highest antimicrobial activity, and dapsone (9/33) exhibited the lowest activity against the tested strains. Cefoxitin (30/33), cefoperazone (28/33), and cefepime (28/33) were effective against a high proportion of strains, and macrolides were also highly effective as well as offering the benefit of convenient oral administration to patients. Linezolid (27/33), meropenem (26/33), sulfamethoxazole (26/33), and tigecycline (25/33) showed the highest activity; clofazimine (20/33) and doxycycline (18/33) showed intermediate activity; and rifapentine (13/33), rifabutin (13/33), and minocycline (11/33) showed low antimicrobial activity, closely followed by thioacetazone (10/33) and pasiniazid (10/33), against the tested organisms. According to their susceptibility profiles, the slowly growing species and were the least susceptible to the tested drugs, whereas , , , , , and were the most susceptible. . In summary, cephalosporins and macrolides, particularly cefmetazole, azithromycin, clarithromycin, and roxithromycin, showed good antimicrobial activity against the reference strains of SGM.
.. 缓慢生长分枝杆菌（SGM）在全球广泛存在，可引起广泛的疾病谱。.. 在这项研究中，使用改良微量稀释法测试了 33 株 SGM 参考菌株对 19 种抗菌药物的药敏性。.. 头孢美唑（33/33）和阿奇霉素（33/33）表现出最高的抗菌活性，而磺胺二甲嘧啶（9/33）对测试菌株的活性最低。头孢西丁（30/33）、头孢哌酮（28/33）和头孢吡肟（28/33）对大部分菌株有效，大环内酯类药物也具有高度活性，并且为患者提供了口服给药的便利。利奈唑胺（27/33）、美罗培南（26/33）、磺胺甲噁唑（26/33）和替加环素（25/33）表现出最高的活性；氯法齐明（20/33）和强力霉素（18/33）表现出中等活性；利福喷丁（13/33）、利福布汀（13/33）和米诺环素（11/33）表现出低抗菌活性，紧随其后的是硫代乙酰胺（10/33）和对氨基水杨酸（10/33），对测试的微生物。根据其药敏谱，缓慢生长的种 和 对测试药物的敏感性最低，而 、 、 、 、 和 最敏感。.. 综上所述，头孢菌素类和大环内酯类，特别是头孢美唑、阿奇霉素、克拉霉素和罗红霉素，对 SGM 参考菌株表现出良好的抗菌活性。
