Department of Clinical Laboratory, Bengbu Medical College, Bengbu, Anhui 233030, China.
Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
Biomed Res Int. 2017;2017:9679843. doi: 10.1155/2017/9679843. Epub 2017 Apr 23.
Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB). The association between HBV infection and human leukocyte antigen- (HLA-) DQ polymorphism (rs2856718 and rs7453920) has been demonstrated in other studies; however, the results were controversial or inconclusive. Therefore, to derive a more precise estimation of the association, a meta-analysis was performed. Crude odds ratios (ORs) and their 95% confidence intervals (CIs) were used to assess the strength of association between HLA-DQ polymorphism (rs2856718 and rs7453920) and HBV infection risk. A total of 11 articles were used to evaluate the effect of the two polymorphisms on risk of HBV infection. The pooled data showed that HLA-DQ rs2856718-G polymorphism showed protection against HBV infection, and rs2856718-A was a risk factor for chronic HBV infection. The pooled risk estimates indicated that HLA-DQ rs7453920-A polymorphism was associated with decreased risk of HBV infection, and rs7453920-G serves as a risk factor in HBV infection. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers; further investigation on a large population and different ethnicities is warranted.
乙型肝炎病毒（HBV）感染是慢性乙型肝炎（CHB）的主要危险因素。其他研究已经证明了 HBV 感染与人类白细胞抗原（HLA）-DQ 多态性（rs2856718 和 rs7453920）之间存在关联；然而，结果存在争议或不明确。因此，进行了荟萃分析以得出更精确的关联估计。使用粗比值比（OR）及其 95％置信区间（CI）来评估 HLA-DQ 多态性（rs2856718 和 rs7453920）与 HBV 感染风险之间的关联强度。共有 11 篇文章用于评估这两种多态性对 HBV 感染风险的影响。汇总数据表明，HLA-DQ rs2856718-G 多态性对 HBV 感染具有保护作用，而 rs2856718-A 是慢性 HBV 感染的危险因素。汇总的风险估计表明，HLA-DQ rs7453920-A 多态性与 HBV 感染风险降低相关，而 rs7453920-G 是 HBV 感染的危险因素。然而，由于相关研究数量的限制，这些分层分析缺乏可信度；需要在更大的人群和不同种族中进行进一步的调查。
