Department of Orthopaedics, University of Utah, Salt Lake City, Utah.
George E. Wahlen Department of Veterans Affairs, Salt Lake City, Utah.
J Biomed Mater Res A. 2017 Sep;105(9):2632-2639. doi: 10.1002/jbm.a.36112. Epub 2017 Jun 27.
Orthodontic retention has been proposed as a life-long commitment for patients who desire to maintain straight teeth. However, the presence of foreign material increases risk of bacterial colonization and caries formation, of which Streptococcus mutans is a key contributor. Multiple studies have assessed the ability of silver to be added to base plate material and resist attachment of S. mutans. However, it does not appear that long-term washout in connection with biofilm growth under physiologically relevant conditions has been taken into consideration. In this study, silver was added to base plate material and exposed to short- or long-term washout periods. Materials were then assessed for their ability to resist biofilm formation of S. mutans using a drip flow reactor that modeled the human oral environment. Data indicated that silver was able to resist biofilm formation following short-term washout, but long-term washout periods resulted in a lack of ability to resist biofilm formation. These data will be important for future development of base plate materials to achieve long-term antimicrobial efficacy to reduce risk of caries formation and benefit patients in the long term. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2632-2639, 2017.
正畸保持被认为是患者维持直齿的终身承诺。然而，异物的存在会增加细菌定植和龋齿形成的风险，其中变形链球菌是一个关键因素。多项研究评估了在基板材料中添加银并抵抗变形链球菌附着的能力。然而，似乎没有考虑到在生理相关条件下与生物膜生长相关的长期冲洗。在这项研究中，银被添加到基板材料中，并暴露于短期或长期冲洗期。然后使用模拟人体口腔环境的滴流反应器评估材料抵抗变形链球菌生物膜形成的能力。数据表明，银在短期冲洗后能够抵抗生物膜形成，但长期冲洗会导致无法抵抗生物膜形成。这些数据对于未来基板材料的开发将是重要的，以实现长期的抗菌效果，降低龋齿形成的风险，并从长远来看使患者受益。© 2017 威利父子公司。J 生物医学材料研究部分 A:105A:2632-2639，2017。
