Maurer B, Flügel R M
Institut für Virusforschung, Deutsches Krebsforschungszentrum, Heidelberg, FRG.
AIDS Res Hum Retroviruses. 1988 Dec;4(6):467-73. doi: 10.1089/aid.1988.4.467.
The human spumaretrovirus (HSRV) isolated from a nasopharynx carcinoma patient 17 years ago has a RNA genome 11 kb in size. It encodes besides the gag, pol, and env genes several novel genes (S1 and bel 1, 2, and 3) that are comparable to the regulatory genes R, X, tat, art, and 3'-orf of the human (HIVs) and simian immunodeficiency viruses (SIVs) with respect to genomic location and to sizes of the putative gene products. A comparison between the HIV protein sequences of the pol and the novel genes to the corresponding gene product sequences of HSRV revealed that HSRV is related to the lentiviruses but occupies a distinct phylogenetic placement of its own. A detailed analysis of the reverse transcriptase domain allows the construction of a phylogenetic tree for the known retroviral subfamilies and/or groups, including the oncoviruses, the lentiviruses, the spumaviruses, the HLTV-BLV group, and the D-type viruses. Regions of the putative novel HSRV gene products with segmental protein sequence homology to the regulatory protein of other human retroviruses are discussed. The results strengthen the view that HSRV and its novel genes should be studied in comparison to the new genes of acquired immunodeficiency syndrome (AIDS) viruses and human T cell leukemia viruses (HTLV).
17年前从一名鼻咽癌患者体内分离出的人类泡沫逆转录病毒（HSRV），其RNA基因组大小为11 kb。除了gag、pol和env基因外，它还编码几个新基因（S1和bel 1、2、3），这些新基因在基因组位置和推定基因产物大小方面，与人类免疫缺陷病毒（HIV）和猴免疫缺陷病毒（SIV）的调节基因R、X、tat、art和3'-orf相当。将HIV的pol基因和新基因的蛋白质序列与HSRV相应的基因产物序列进行比较后发现，HSRV与慢病毒有关，但在系统发育上有其独特的位置。对逆转录酶结构域的详细分析有助于构建已知逆转录病毒亚科和/或组的系统发育树，包括肿瘤病毒、慢病毒、泡沫病毒、HTLV-BLV组和D型病毒。文中讨论了推定的HSRV新基因产物中与其他人类逆转录病毒调节蛋白具有部分蛋白质序列同源性的区域。这些结果强化了一种观点，即应将HSRV及其新基因与获得性免疫缺陷综合征（AIDS）病毒和人类T细胞白血病病毒（HTLV）的新基因进行比较研究。
