Krantis A, Kerr D I
Eur J Pharmacol. 1981 Nov 19;76(1):111-4. doi: 10.1016/0014-2999(81)90018-2.
Possible involvement of gamma-aminobutyric acid (GABA) in intestinal motility of the guinea-pig has been investigated using the speed of propulsion of faecal pellets along isolated segments of guinea-pig distal colon, and the rate of pellet expulsion from freshly excised colon. GABA antagonism, by bicuculline or by tachyphylaxis to GABA, substantially reduced intestinal motility and generally reduced the amplitude of the reflex contraction associated with pellet propulsion. These results support the view that GABAergic mechanisms may be involved in the propulsive activity of the guinea-pig distal colon.
利用粪便颗粒沿豚鼠远端结肠离体节段的推进速度以及从新鲜切除的结肠中排出颗粒的速率，研究了γ-氨基丁酸（GABA）在豚鼠肠道运动中的可能作用。荷包牡丹碱或对GABA产生快速耐受性所导致的GABA拮抗作用，显著降低了肠道运动，并普遍降低了与颗粒推进相关的反射收缩幅度。这些结果支持了GABA能机制可能参与豚鼠远端结肠推进活动的观点。
