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微型巩膜镜在类天疱疮中的作用

Role of mini-scleral lens in mucous membrane pemphigoid.

作者信息

Kumar Mukesh, Shetty Rohit, Jayadev Chaitra

机构信息

Narayana Nethralaya, Bengaluru, Karnataka, India.

出版信息

Indian J Ophthalmol. 2017 Apr;65(4):320-322. doi: 10.4103/ijo.IJO_730_16.

DOI:10.4103/ijo.IJO_730_16
PMID:28513499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5452587/
Abstract

This study aims to report the use of mini-scleral contact lens in the management of mucous membrane pemphigoid (MMP) with persistent epithelial defects. A 68-year-old male with a history of ocular pain and declining visual acuity was referred to our clinic with a diagnosis of MMP. His corrected distance visual acuity (CDVA) was 20/200 in the right eye and 20/100 in the left eye. Despite being on lubricants, topical steroids and intravenous cyclophosphamide, the patient developed persistent corneal epithelial defects in both eyes. He was then given a trial of mini-scleral lenses. Within 4 weeks, corneal epithelial defects healed, and at 6 months, the CDVA had improved to 20/50 in the right eye and 20/40 in the left eye. By improving the corneal surface integrity and visual function, mini-scleral lenses can play a role in the visual rehabilitation of patients with MMP.

摘要

本研究旨在报告微型巩膜接触镜在治疗伴有持续性上皮缺损的黏膜类天疱疮(MMP)中的应用。一名68岁男性,有眼痛和视力下降病史,因MMP诊断被转诊至我院。他的右眼矫正远视力(CDVA)为20/200,左眼为20/100。尽管使用了润滑剂、局部类固醇和静脉注射环磷酰胺,患者双眼仍出现持续性角膜上皮缺损。随后给他试用微型巩膜镜。4周内,角膜上皮缺损愈合,6个月时,右眼CDVA提高到20/50,左眼提高到20/40。通过改善角膜表面完整性和视觉功能,微型巩膜镜可在MMP患者的视觉康复中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa35/5452587/c6aff2d4e479/IJO-65-320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa35/5452587/c6aff2d4e479/IJO-65-320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa35/5452587/c6aff2d4e479/IJO-65-320-g001.jpg

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本文引用的文献

1
Ocular cicatricial pemphigoid: the role of scleral lenses in disease management.眼瘢痕性类天疱疮:巩膜镜在疾病管理中的作用。
Cornea. 2009 Dec;28(10):1170-2. doi: 10.1097/ICO.0b013e318199fa56.
2
Jupiter scleral lenses in the management of chronic graft versus host disease.朱庇特巩膜镜在慢性移植物抗宿主病治疗中的应用
Eye Contact Lens. 2008 Nov;34(6):302-5. doi: 10.1097/ICL.0b013e318188e205.
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Advances in understanding and managing dry eye disease.干眼症诊治的进展
圆锥角膜中使用特定微型巩膜接触镜模型对临床结果进行表征和预测。
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Fluid-ventilated, gas-permeable scleral contact lens is an effective option for managing severe ocular surface disease and many corneal disorders that would otherwise require penetrating keratoplasty.液体通气、透气的巩膜接触镜是治疗严重眼表疾病和许多角膜疾病的有效选择,否则这些疾病可能需要穿透性角膜移植术。
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The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators.关于黏膜类天疱疮的首个国际共识:定义、诊断标准、致病因素、医学治疗及预后指标。
Arch Dermatol. 2002 Mar;138(3):370-9. doi: 10.1001/archderm.138.3.370.
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The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid.严重眼部瘢痕性类天疱疮患者的治疗效果及其相关副作用
Ophthalmology. 2002 Jan;109(1):111-8. doi: 10.1016/s0161-6420(01)00863-6.
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Scleral contact lenses for overnight wear in the management of ocular surface disorders.用于眼表疾病管理的过夜佩戴巩膜接触镜。
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10
Treatment of persistent corneal epithelial defect with extended wear of a fluid-ventilated gas-permeable scleral contact lens.使用透气巩膜软性接触镜长戴治疗持续性角膜上皮缺损
Am J Ophthalmol. 2000 Jul;130(1):33-41. doi: 10.1016/s0002-9394(00)00379-2.