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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Shimokawa H, Aarhus L L, Vanhoutte P M

Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905.

Br J Pharmacol. 1988 Dec;95(4):1191-6. doi: 10.1111/j.1476-5381.1988.tb11755.x.

The effects of chronic dietary supplementation with omega 3 polyunsaturated fatty acids on endothelium-dependent relaxations were examined in isolated coronary microvessels of the pig. 2. Animals were maintained for four weeks with or without dietary supplementation of purified eicosapentaenoic acid (3.5 g daily) and docosahexaenoic acid (1.5 g daily). Fatty acid profiles of plasma lipids showed that only the fraction of eicosapentaenoic acid increased by the treatment, together with a decrease of that of arachidonic acid. 3. In the treated group, endothelium-dependent relaxations to bradykinin were significantly augmented, while contractions to acetylcholine or relaxations to nitroprusside were unaltered. 4. These results indicate that dietary omega 3 polyunsaturated fatty acids (mainly eicosapentaenoic acid) augment endothelium-dependent relaxations in coronary microvessels of the pig, without changing the ability of vascular smooth muscle to contract or relax.

在猪的离体冠状动脉微血管中研究了长期膳食补充ω-3多不饱和脂肪酸对内皮依赖性舒张的影响。2. 动物在有或无膳食补充纯化的二十碳五烯酸（每日3.5克）和二十二碳六烯酸（每日1.5克）的情况下维持四周。血浆脂质的脂肪酸谱显示，治疗仅使二十碳五烯酸的比例增加，同时花生四烯酸的比例降低。3. 在治疗组中，对缓激肽的内皮依赖性舒张显著增强，而对乙酰胆碱的收缩或对硝普钠的舒张未改变。4. 这些结果表明，膳食中的ω-3多不饱和脂肪酸（主要是二十碳五烯酸）可增强猪冠状动脉微血管中的内皮依赖性舒张，而不改变血管平滑肌收缩或舒张的能力。

Shimokawa H, Aarhus L L, Vanhoutte P M

Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905.

Br J Pharmacol. 1988 Dec;95(4):1191-6. doi: 10.1111/j.1476-5381.1988.tb11755.x.

The effects of chronic dietary supplementation with omega 3 polyunsaturated fatty acids on endothelium-dependent relaxations were examined in isolated coronary microvessels of the pig. 2. Animals were maintained for four weeks with or without dietary supplementation of purified eicosapentaenoic acid (3.5 g daily) and docosahexaenoic acid (1.5 g daily). Fatty acid profiles of plasma lipids showed that only the fraction of eicosapentaenoic acid increased by the treatment, together with a decrease of that of arachidonic acid. 3. In the treated group, endothelium-dependent relaxations to bradykinin were significantly augmented, while contractions to acetylcholine or relaxations to nitroprusside were unaltered. 4. These results indicate that dietary omega 3 polyunsaturated fatty acids (mainly eicosapentaenoic acid) augment endothelium-dependent relaxations in coronary microvessels of the pig, without changing the ability of vascular smooth muscle to contract or relax.

在猪的离体冠状动脉微血管中研究了长期膳食补充ω-3多不饱和脂肪酸对内皮依赖性舒张的影响。2. 动物在有或无膳食补充纯化的二十碳五烯酸（每日3.5克）和二十二碳六烯酸（每日1.5克）的情况下维持四周。血浆脂质的脂肪酸谱显示，治疗仅使二十碳五烯酸的比例增加，同时花生四烯酸的比例降低。3. 在治疗组中，对缓激肽的内皮依赖性舒张显著增强，而对乙酰胆碱的收缩或对硝普钠的舒张未改变。4. 这些结果表明，膳食中的ω-3多不饱和脂肪酸（主要是二十碳五烯酸）可增强猪冠状动脉微血管中的内皮依赖性舒张，而不改变血管平滑肌收缩或舒张的能力。