膳食中的ω-3多不饱和脂肪酸可增强猪冠状动脉微血管中内皮依赖性缓激肽介导的舒张作用。
Dietary omega 3 polyunsaturated fatty acids augment endothelium-dependent relaxation to bradykinin in coronary microvessels of the pig.
作者信息
Shimokawa H, Aarhus L L, Vanhoutte P M
机构信息
Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905.
出版信息
Br J Pharmacol. 1988 Dec;95(4):1191-6. doi: 10.1111/j.1476-5381.1988.tb11755.x.
Abstract
- The effects of chronic dietary supplementation with omega 3 polyunsaturated fatty acids on endothelium-dependent relaxations were examined in isolated coronary microvessels of the pig. 2. Animals were maintained for four weeks with or without dietary supplementation of purified eicosapentaenoic acid (3.5 g daily) and docosahexaenoic acid (1.5 g daily). Fatty acid profiles of plasma lipids showed that only the fraction of eicosapentaenoic acid increased by the treatment, together with a decrease of that of arachidonic acid. 3. In the treated group, endothelium-dependent relaxations to bradykinin were significantly augmented, while contractions to acetylcholine or relaxations to nitroprusside were unaltered. 4. These results indicate that dietary omega 3 polyunsaturated fatty acids (mainly eicosapentaenoic acid) augment endothelium-dependent relaxations in coronary microvessels of the pig, without changing the ability of vascular smooth muscle to contract or relax.
摘要
- 在猪的离体冠状动脉微血管中研究了长期膳食补充ω-3多不饱和脂肪酸对内皮依赖性舒张的影响。2. 动物在有或无膳食补充纯化的二十碳五烯酸（每日3.5克）和二十二碳六烯酸（每日1.5克）的情况下维持四周。血浆脂质的脂肪酸谱显示，治疗仅使二十碳五烯酸的比例增加，同时花生四烯酸的比例降低。3. 在治疗组中，对缓激肽的内皮依赖性舒张显著增强，而对乙酰胆碱的收缩或对硝普钠的舒张未改变。4. 这些结果表明，膳食中的ω-3多不饱和脂肪酸（主要是二十碳五烯酸）可增强猪冠状动脉微血管中的内皮依赖性舒张，而不改变血管平滑肌收缩或舒张的能力。
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