Department of Kinesiology, New Mexico State University, Las Cruces, NM 88003, USA.
Nutrients. 2023 Oct 25;15(21):4516. doi: 10.3390/nu15214516.
Menopause is a condition associated with an increased risk of dysregulation in cardiovascular and metabolic health among older women. While fish oil (FO) has garnered great attention for its health-enhancing properties, its potential for enhancing cardiometabolic health in this demographic remains to be established. The purpose of this study was to determine the clinical efficacy of an 8 wk administration of FO combined with programmed resistance exercise training (RET) on physical function and risk factors associated with cardiometabolic health in healthy older women. Twenty, healthy, older women were randomly assigned to one of the two experimental groups: resistance training with placebo (RET-PL) or RET with fish oil (RET-FO). Physical function, blood pressure (BP), triglyceride (TG), and systemic inflammation and oxidative stress biomarkers were assessed before and after the intervention. Statistical significance was set at ≤ 0.05. Physical function was greatly enhanced in both RET and RET-FO. Handgrip strength substantially increased only in RET-FO. RET-FO exhibited significant decreases in BP, TG, inflammatory cytokines (TNF-α and IL-6), and oxidative stress (MDA and 8-OHdG) levels, while no detectable changes were found in RET-PL. Our findings indicate that FO administration during 8 wks of RET appears to enhance muscle function and lower risk factors linked to cardiometabolic disorders in postmenopausal women.
绝经是与老年女性心血管和代谢健康失调风险增加相关的一种状况。虽然鱼油 (FO) 因其具有增强健康的特性而备受关注，但它在这一年龄段增强心脏代谢健康的潜力尚未得到证实。本研究旨在确定 FO 联合程序化抵抗运动训练 (RET) 对健康老年女性身体功能和与心脏代谢健康相关的风险因素的临床疗效。20 名健康的老年女性被随机分配到以下两个实验组之一：安慰剂 (RET-PL) 或鱼油 (RET-FO) 结合阻力训练。在干预前后评估身体功能、血压 (BP)、甘油三酯 (TG) 以及全身炎症和氧化应激生物标志物。统计显著性设置为 ≤ 0.05。RET 和 RET-FO 均显著增强了身体功能。仅在 RET-FO 中，握力显著增加。RET-FO 显著降低了血压、TG、炎症细胞因子 (TNF-α 和 IL-6) 和氧化应激 (MDA 和 8-OHdG) 水平，而 RET-PL 未发现任何变化。我们的研究结果表明，在 8 周的 RET 期间进行 FO 给药似乎可以增强肌肉功能并降低绝经后女性与心脏代谢紊乱相关的风险因素。
