源自2,2'-二羟基-1,1'-联芳基的张力炔烃；合成及其与叠氮化物的无铜环加成反应
Strained alkynes derived from 2,2'-dihydroxy-1,1'-biaryls; synthesis and copper-free cycloaddition with azides.
作者信息
Del Grosso Alessandro, Galanopoulos Lavrentis-Dimitrios, Chiu Cookson K C, Clarkson Guy J, O Connor Peter B, Wills Martin
机构信息
Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK.
出版信息
Org Biomol Chem. 2017 May 31;15(21):4517-4521. doi: 10.1039/c7ob00991g.
A series of strained alkynes were prepared from 2,2'-dihydroxy-biaryls. Several were characterised by X-ray crystallography, revealing strained C(sp)-C(sp)-C(sp) bond angles in the range of 163-167°. Their cycloadditions with azides proceed without a catalyst. Functionalised versions of these reagents have potential applications to materials synthesis and bioconjugations.
一系列张力炔烃由2,2'-二羟基联芳基制备而成。其中几种通过X射线晶体学进行了表征，结果显示张力C(sp)-C(sp)-C(sp)键角在163°至167°范围内。它们与叠氮化物的环加成反应无需催化剂即可进行。这些试剂的功能化版本在材料合成和生物共轭方面具有潜在应用。
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