Husain K, Ansari R A
Industrial Toxicology Research Centre, Lucknow, India.
Can J Physiol Pharmacol. 1988 Sep;66(9):1144-7. doi: 10.1139/y88-188.
Diazinon, an organophosphorous compound, produced hyperglycemia and reduced the glycogen content of the brain 2 h after its administration to rats (40 mg/kg, i.p.). The activities of the glycogenolytic enzymes, glycogen phosphorylase and phosphoglucomutase, were significantly increased, while that of glucose-6-phosphatase was not altered. Atropine (20 mg/kg, i.p.) given immediately after diazinon abolished the changes; tolazoline or propranolol (each at 10 mg/kg, i.p.) injected 30 min before the administration of diazinon significantly reduced the hyperglycemia and the increase in brain glycogenolysis. A combination of tolazoline and propranolol was more effective than either of them alone and completely abolished the hyperglycemia and the changes in brain glycogenolysis. It may be concluded that diazinon initially activates central cholinergic processes leading to hyperglycemia and increased cerebral glycogenolysis in animals.
二嗪农是一种有机磷化合物，给大鼠腹腔注射40毫克/千克后2小时，它会导致血糖升高并降低大脑中的糖原含量。糖原分解酶、糖原磷酸化酶和磷酸葡萄糖变位酶的活性显著增加，而葡萄糖-6-磷酸酶的活性没有改变。二嗪农给药后立即腹腔注射阿托品（20毫克/千克）可消除这些变化；在二嗪农给药前30分钟注射妥拉唑啉或普萘洛尔（均为腹腔注射10毫克/千克）可显著降低高血糖和大脑糖原分解的增加。妥拉唑啉和普萘洛尔联合使用比单独使用任何一种都更有效，并且完全消除了高血糖和大脑糖原分解的变化。可以得出结论，二嗪农最初激活中枢胆碱能过程，导致动物血糖升高和大脑糖原分解增加。
