Matin M A, Husain K
Biochem Pharmacol. 1987 Jun 1;36(11):1815-7. doi: 10.1016/0006-2952(87)90243-7.
Treatment with malathion resulted in an increase in the level of blood glucose and lactate and reduced cerebral glycogen, 2 hr after its administration. The blood pyruvate level was not changed. The activities of glycogenolytic enzymes (glycogen phosphorylase and phosphoglucomutase) were increased significantly in the brain, whereas that of glucose-6-phosphatase remained unchanged. The activity of the glycolytic enzyme-hexokinase was increased significantly in malathion-treated animals, whereas those of the glucose-6-phosphate and lactate dehydrogenases were not significantly changed. The changes in enzyme activities may be a compensatory mechanism to provide energy in the form of glucose to cerebral tissue on account of stimulatory effects in malathion-treated animals.
马拉硫磷给药2小时后，治疗导致血糖和乳酸水平升高，脑糖原减少。血丙酮酸水平未改变。脑内糖原分解酶（糖原磷酸化酶和磷酸葡萄糖变位酶）的活性显著增加，而葡萄糖-6-磷酸酶的活性保持不变。在接受马拉硫磷治疗的动物中，糖酵解酶己糖激酶的活性显著增加，而葡萄糖-6-磷酸脱氢酶和乳酸脱氢酶的活性没有显著变化。酶活性的变化可能是一种补偿机制，由于马拉硫磷对动物的刺激作用，以葡萄糖的形式为脑组织提供能量。
