Shanghai Institution of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Department of Radiology, Eye & ENT Hospital of Fudan University, Shanghai, P.R. China.
J Magn Reson Imaging. 2017 Dec;46(6):1760-1766. doi: 10.1002/jmri.25760. Epub 2017 May 17.
To determine the feasibility of intravoxel incoherent motion (IVIM) for characterizing perfusion properties and its potential diagnostic utility for nonarteritic anterior ischemic optic neuropathy (NAION). IVIM diffusion-weighted imaging is a promising technique that can measure perfusion and diffusion characteristics simultaneously in a noninvasive manner.
Orbital IVIM in a 3.0T scanner was performed on 33 patients with NAION and 15 controls using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition (RESOLVE-IVIM). Both visual field (VF) and visual acuity (VA) examinations were performed in 19 of the patients. The vascular volume fraction (f), diffusion coefficient (D), and pseudodiffusion coefficient (D*) were calculated for quantitative analysis. Additionally, correlation analyses of IVIM parameters with visual function were also performed.
Affected optic nerves showed significantly lower f values than both unaffected contralateral nerves of the patients and nerves of the controls (P < 0.0001), and no significant difference for f was found between unaffected contralateral nerves and nerves of the controls (P = 0.1602). In addition, D and D* values showed no significant differences among the three groups (P = 0.0979, 0.0600, 0.6136 for D and 0.1779, 0.6253, 0.4743 for D*). Correlation analysis only demonstrated significant correlations between f values and the mean deviation of the visual field (r = 0.576, P = 0.0051).
RESOLVE-IVIM measurement may reflect the perfusion abnormality and visual function impairment in NAION patients, demonstrating its potential application for the diagnosis and clinical evaluation of NAION.
1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1760-1766.
确定体素内不相干运动（IVIM）在表征灌注特性中的可行性及其在非动脉炎性前部缺血性视神经病变（NAION）中的潜在诊断价值。IVIM 扩散加权成像技术是一种很有前途的技术，可以非侵入性地同时测量灌注和扩散特性。
使用读出分段回波平面成像、并行成像和二维导航器重采（RESOLVE-IVIM）在 3.0T 扫描仪上对 33 例 NAION 患者和 15 例对照者进行眼眶 IVIM。19 例患者进行了视野（VF）和视力（VA）检查。对定量分析计算血管容积分数（f）、扩散系数（D）和假性扩散系数（D*）。此外，还对 IVIM 参数与视觉功能的相关性进行了分析。
受影响的视神经 f 值明显低于患者的未受影响的对侧神经和对照组的神经（P<0.0001），未受影响的对侧神经和对照组的神经之间的 f 值无显著差异（P=0.1602）。此外，三组间 D 和 D值无显著差异（P=0.0979、0.0600、0.6136 为 D 值和 0.1779、0.6253、0.4743 为 D值）。相关性分析仅显示 f 值与视野平均偏差之间存在显著相关性（r=0.576，P=0.0051）。
RESOLVE-IVIM 测量可能反映了 NAION 患者的灌注异常和视觉功能障碍，表明其在 NAION 的诊断和临床评估中有应用潜力。
1 技术功效：第 3 阶段 J. Magn. Reson. Imaging 2017；46：1760-1766。
