Milyutina Yu P, Pustygina A V, Zaloznyaya I V, Arutjunyan A V
D.O.Ott Institute of Obstetrics, Gynecology and Reproductology, Saint-Petersburg, 199034, Russian Federation;
Adv Gerontol. 2016;29(2):239-246.
The article presents a detailed analysis of correlations between the content of a variety of biogenic amines in the hypothalamic structures responsible for the luteinizing hormone releasing hormone synthesis and secretion (the medial preoptic area and median eminence) and such independent factors as total L-homocysteine plasma level elevation induced by L-methionine loading and aging. Both a nature and a pattern of changes in oxidative stress profile were evaluated. It was shown that ageing, when compared to hyperhomocysteinemia, is a determining factor influencing biogenic amine content in the studied hypothalamic structures. Unlike antioxidant defense system profile, considerable changes in macromolecule oxidative modification were not found, which evidences a balanced activity of pro- and antioxidant systems in the hypothalamus.
本文详细分析了负责促黄体生成素释放激素合成与分泌的下丘脑结构（内侧视前区和正中隆起）中多种生物胺的含量与诸如L-蛋氨酸负荷诱导的血浆总L-同型半胱氨酸水平升高和衰老等独立因素之间的相关性。同时评估了氧化应激谱变化的性质和模式。结果表明，与高同型半胱氨酸血症相比，衰老才是影响所研究下丘脑结构中生物胺含量的决定性因素。与抗氧化防御系统谱不同，未发现大分子氧化修饰有显著变化，这表明下丘脑的促氧化和抗氧化系统活性平衡。
