Gorbunova A V, Salieva R M, Lobanova N N, Ionochkina I N, Petrova S Y, Dedov V I
B.I. Lavrent'ev Laboratory of Neurohistology, P.K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Neurosci Behav Physiol. 1997 Mar-Apr;27(2):145-52. doi: 10.1007/BF02461945.
The levels of biogenic amines and of a number of the products of their metabolism were studied in the hypothalamic nuclei in Wistar and August rats, which have different levels of resistance to emotional stress; levels were also studied in structures functionally and anatomically associated with the hypothalamic nuclei, i.e., the reticular formation of the midbrain, the amygdaloid body, the septum, the locus ceruleus, the dorsal cervical nucleus, and the ventral region of the tegmentum. The genotype was found to determine the level of metabolism of biogenic amines in structures of the central nervous system in conditions of emotional stress. In August rats, the activities of the dopaminergic and serotoninergic systems, which are stress-limiting, decreased to a greater extent during 24-hour immobilization stress. Adrenaline levels in structures of the central nervous system in August rats were higher during stress. Changes in the contents of biogenic amines in the paraventricular and ventromedial nuclei of the hypothalamus in Wistar and August rats could affect the preganglionic neurons of the autonomic nervous system.
研究了对情绪应激具有不同抵抗水平的Wistar大鼠和八月龄大鼠下丘脑核中生物胺及其多种代谢产物的水平；还研究了在功能和解剖学上与下丘脑核相关的结构中的水平，即中脑网状结构、杏仁体、隔区、蓝斑、颈背核以及被盖腹侧区。研究发现，在情绪应激条件下，基因型决定了中枢神经系统结构中生物胺的代谢水平。在八月龄大鼠中，具有应激限制作用的多巴胺能和血清素能系统的活性在24小时固定应激期间下降幅度更大。八月龄大鼠在应激期间中枢神经系统结构中的肾上腺素水平较高。Wistar大鼠和八月龄大鼠下丘脑室旁核和腹内侧核中生物胺含量的变化可能会影响自主神经系统的节前神经元。
