Farràs Llobet Alba, Regincós Martí Laia, Higueras Teresa, Calero Fernández Inés Zulema, Gascón Portalés Andrea, Goya Canino María M, Carreras Moratonas Elena
a Department of Obstetrics , Hospital Vall d'Hebron , Barcelona , Spain.
J Matern Fetal Neonatal Med. 2018 Jul;31(14):1881-1884. doi: 10.1080/14767058.2017.1331427. Epub 2017 Jun 6.
The objective of this study is to determine whether the uterocervical angle (UCA) correlates with the risk of spontaneous preterm birth (sPTB) < 34 weeks and assess its interobserver variability.
Case-control study of 275 women including 34 who started labor spontaneously and gave birth before 34 weeks of gestation (preterm group) and 241 who gave birth at term (control group). Images used to report cervical length were re-measured for UCA.
Mean UCA in the second trimester was wider in the preterm group (105.16°) compared with the control group (94.53°), p = .015. The intraclass correlation coefficient was 0.821 (95% CI: 0.74-0.97) for masked interobserver variability, which implies correct agreement among UCA measurements. Mean UCA increased from the first to the second trimester (84.2° versus 94.5°; p = .019).
Wider UCA in the second trimester is related to sPTB. UCA measurement is a reproducible technique. UCA appears to increase from the first to the second trimester. Prospective studies, with ultrasound examinations aimed at measuring UCA in vivo, are needed to accurately assess the characteristics of this marker and its potential as a predictor of sPTB in clinical practice.
本研究的目的是确定子宫颈角度（UCA）是否与孕周小于34周的自发性早产（sPTB）风险相关，并评估其观察者间的变异性。
对275名女性进行病例对照研究，其中包括34名自发开始分娩并在妊娠34周前分娩的女性（早产组）和241名足月分娩的女性（对照组）。重新测量用于报告宫颈长度的图像以获取UCA。
与对照组（94.53°）相比，早产组孕中期的平均UCA更宽（105.16°），p = 0.015。对于掩盖的观察者间变异性，组内相关系数为0.821（95%CI：0.74 - 0.97），这意味着UCA测量之间的一致性正确。平均UCA从孕早期到孕中期增加（84.2°对94.5°；p = 0.019）。
孕中期较宽的UCA与sPTB相关。UCA测量是一种可重复的技术。UCA似乎从孕早期到孕中期增加。需要进行前瞻性研究，通过超声检查在体内测量UCA，以准确评估该标志物的特征及其在临床实践中作为sPTB预测指标的潜力。
