Smith Wade P, Young Lori A, Phillips Mark H, Cheung Michael, Halasz Lia M, Rockhill Jason K
Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA.
Harborview Medical Center, Seattle, WA, USA.
Technol Cancer Res Treat. 2017 Dec;16(6):893-899. doi: 10.1177/1533034617708884. Epub 2017 May 17.
Multisession stereotactic radiation therapy is increasingly being seen as a preferred option for intracranial diseases in close proximity to critical structures and for larger target volumes. The objective of this study is to investigate the reproducibility of the Extend system from Elekta. A retrospective review was conducted for all patients treated with multisession Gamma Knife between July 2010 and June 2015, including both malignant and benign lesions. Eighty-four patients were treated in this 5-year span. The average residual daily setup uncertainty was 0.48 (0.19) mm. We compare measurements of setup uncertainty from the Extend system to measurements performed with a linac-based approach previously used in our center. The Extend system has significantly reduced setup uncertainty for fractionated intracranial treatments at our institution. Positive results were observed in a small population of edentulous patients. The Extend system compares favorably with other approaches to delivering intracranial stereotactic radiotherapy and is a robust, simple-to-use, and precise method for treating multisession intracranial lesions.
多疗程立体定向放射治疗越来越被视为治疗紧邻关键结构的颅内疾病以及较大靶体积疾病的首选方案。本研究的目的是调查医科达公司Extend系统的可重复性。对2010年7月至2015年6月期间接受多疗程伽玛刀治疗的所有患者进行了回顾性研究，包括恶性和良性病变。在这5年期间共治疗了84例患者。平均每日残余摆位不确定性为0.48（0.19）毫米。我们将Extend系统的摆位不确定性测量结果与我们中心之前使用的基于直线加速器的方法所进行的测量结果进行了比较。在我们机构，Extend系统显著降低了分次颅内治疗的摆位不确定性。在一小部分无牙患者中观察到了积极结果。与其他颅内立体定向放射治疗方法相比，Extend系统具有优势，是一种用于治疗多疗程颅内病变的可靠、易用且精确的方法。
