Hunt Mark J, Kopell Nancy J, Traub Roger D, Whittington Miles A
Hull York Medical School, University of York, Heslington, YO10 5DD, UK.
Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
Trends Neurosci. 2017 Jun;40(6):371-382. doi: 10.1016/j.tins.2017.04.003. Epub 2017 May 14.
Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely equivocal, but stronger for lower (delta) than for higher (gamma) bands. However, region-specific changes in rhythms across multiple, interdependent, nested frequencies may correlate better with pathology. Changes in synaptic excitation and inhibition in schizophrenia disrupt delta rhythm-mediated cortico-cortical communication, while enhancing thalamocortical communication in this frequency band. The contrasting relationships between delta and higher frequencies in thalamus and cortex generate frequency mismatches in inter-regional connectivity, leading to a disruption in temporal communication between higher-order brain regions associated with mental time travel.
与精神分裂症相关的大脑动态变化在很大程度上并不明确，许多因素使其解释变得复杂，如治疗药物的存在以及该综合征本身的复杂性。所有患者共有的个体网络振荡在全脑范围内发生变化的证据在很大程度上并不明确，但低频（δ波）比高频（γ波）的证据更强。然而，多个相互依赖、嵌套频率的节律在区域特异性上的变化可能与病理状况有更好的相关性。精神分裂症中突触兴奋和抑制的变化会破坏δ波节律介导的皮质-皮质通信，同时增强该频段的丘脑-皮质通信。丘脑和皮质中δ波与高频之间的对比关系在区域间连接中产生频率不匹配，导致与心理时间旅行相关的高阶脑区之间的时间通信中断。
