能量代谢途径控制着髓系免疫细胞的命运和功能。
Energy metabolic pathways control the fate and function of myeloid immune cells.
作者信息
Al-Khami Amir A, Rodriguez Paulo C, Ochoa Augusto C
机构信息
Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA;
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
出版信息
J Leukoc Biol. 2017 Aug;102(2):369-380. doi: 10.1189/jlb.1VMR1216-535R. Epub 2017 May 17.
Abstract
The past decade has seen a significant interest in investigating the intracellular metabolism of cells of the immune system. This has increased the realization that immune cells endure metabolic reprogramming upon responding to pathogen-derived or inflammatory signals. More importantly, not only does this metabolic switch provide for the bioenergetic and biosynthetic demands but also it, in a highly specific manner, determines the cellular fate and function. In this review, we discuss the metabolic aspects that regulate the differentiation and function of myeloid cells, pivotal for both innate and adaptive immunity. The manipulation of these pathways can alter the function of these cells and therefore, could provide novel therapeutic approaches in cancer and other chronic inflammatory conditions.
摘要
在过去十年中，人们对研究免疫系统细胞的细胞内代谢产生了浓厚兴趣。这使人们越来越认识到，免疫细胞在对病原体衍生或炎症信号作出反应时会经历代谢重编程。更重要的是，这种代谢转换不仅满足了生物能量和生物合成的需求，而且还以高度特异性的方式决定了细胞的命运和功能。在这篇综述中，我们讨论了调节髓样细胞分化和功能的代谢方面，髓样细胞对先天免疫和适应性免疫都至关重要。对这些途径的操纵可以改变这些细胞的功能，因此，可能为癌症和其他慢性炎症性疾病提供新的治疗方法。
相似文献
1
Energy metabolic pathways control the fate and function of myeloid immune cells.能量代谢途径控制着髓系免疫细胞的命运和功能。
J Leukoc Biol. 2017 Aug;102(2):369-380. doi: 10.1189/jlb.1VMR1216-535R. Epub 2017 May 17.
2
Metabolic regulation of innate immunity.先天免疫的代谢调控。
Adv Immunol. 2020;145:129-157. doi: 10.1016/bs.ai.2019.11.005. Epub 2019 Dec 5.
3
Adapted Immune Responses of Myeloid-Derived Cells in Fatty Liver Disease.脂肪性肝病中髓系细胞的适应性免疫反应。
Front Immunol. 2018 Oct 18;9:2418. doi: 10.3389/fimmu.2018.02418. eCollection 2018.
4
Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune Responses.在先天免疫反应中，髓系细胞中细胞代谢的特异性和复杂性重编程。
Cell Metab. 2017 Jul 5;26(1):142-156. doi: 10.1016/j.cmet.2017.06.001.
5
The Intersection of Epigenetics and Metabolism in Trained Immunity.表观遗传学与训练免疫中的代谢的交汇。
Immunity. 2021 Jan 12;54(1):32-43. doi: 10.1016/j.immuni.2020.10.011. Epub 2020 Nov 20.
6
Myeloid-derived suppressor cells: linking inflammation and cancer.髓源性抑制细胞：连接炎症与癌症
J Immunol. 2009 Apr 15;182(8):4499-506. doi: 10.4049/jimmunol.0802740.
7
SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α-dependent glycolysis.SIRT1 通过协调 HIF-1α 依赖性糖酵解来限制肿瘤中髓源抑制性细胞的功能和命运。
Cancer Res. 2014 Feb 1;74(3):727-37. doi: 10.1158/0008-5472.CAN-13-2584. Epub 2013 Dec 18.
8
Editorial: Role of Metabolism in Regulating Immune Cell Fate Decisions.社论：代谢在调节免疫细胞命运决定中的作用
Front Immunol. 2020 Mar 24;11:527. doi: 10.3389/fimmu.2020.00527. eCollection 2020.
9
Metabolic Reprogramming in Mitochondria of Myeloid Cells.髓系细胞线粒体中的代谢重编程。
Cells. 2019 Dec 18;9(1):5. doi: 10.3390/cells9010005.
10
IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation.干扰素调节因子8抑制T细胞中粒细胞-巨噬细胞集落刺激因子的表达，从而影响髓系细胞谱系分化。
J Immunol. 2015 Mar 1;194(5):2369-79. doi: 10.4049/jimmunol.1402412. Epub 2015 Feb 2.
引用本文的文献
1
Effect of the TIM-3/Gal-9 signaling pathway on macrophage polarization in peri-implantitis.TIM-3/Gal-9信号通路对种植体周围炎中巨噬细胞极化的影响
PLoS One. 2025 Jul 18;20(7):e0328258. doi: 10.1371/journal.pone.0328258. eCollection 2025.
2
Pleozymes: Pleiotropic Oxidized Carbon Nanozymes Enhance Cellular Metabolic Flexibility.多效酶：多效性氧化碳纳米酶增强细胞代谢灵活性。
Nanomaterials (Basel). 2024 Dec 15;14(24):2017. doi: 10.3390/nano14242017.
3
Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis.晚期粒细胞生成过程中代谢检查点控制的失败导致网状发育不全中的中性粒细胞减少。
Blood. 2024 Dec 26;144(26):2718-2734. doi: 10.1182/blood.2024024123.
4
TIM-3/Gal-9 interaction affects glucose and lipid metabolism in acute myeloid leukemia cell lines.TIM-3/Gal-9 相互作用影响急性髓系白血病细胞系的糖脂代谢。
Front Immunol. 2023 Nov 10;14:1267578. doi: 10.3389/fimmu.2023.1267578. eCollection 2023.
5
NAMPT/SIRT1 Expression Levels in White Blood Cells Differentiate the Different Rheumatoid Arthritis Subsets: An Inspiration from Traditional Chinese Medicine.白细胞中NAMPT/SIRT1表达水平可区分不同类风湿关节炎亚型：来自中医的启示
J Inflamm Res. 2023 Sep 26;16:4271-4285. doi: 10.2147/JIR.S431600. eCollection 2023.
6
Chronic alcohol administration alters metabolomic profile of murine bone marrow.慢性酒精摄入改变了小鼠骨髓的代谢组学特征。
Front Immunol. 2023 Apr 5;14:1128352. doi: 10.3389/fimmu.2023.1128352. eCollection 2023.
7
Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism.营养药物作为免疫代谢中的潜在治疗调节剂。
Nutrients. 2023 Jan 13;15(2):411. doi: 10.3390/nu15020411.
8
New Perspectives on Myeloid-Derived Suppressor Cells and Their Emerging Role in Haematology.髓源性抑制细胞的新视角及其在血液学中的新兴作用
J Clin Med. 2022 Sep 10;11(18):5326. doi: 10.3390/jcm11185326.
9
Transcriptome analysis of immune cells from Behçet's syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet's syndrome.Behçet 综合征患者免疫细胞的转录组分析：IL-17 产生细胞和抗原提呈细胞在 Behçet 综合征发病机制中的重要性。
Arthritis Res Ther. 2022 Aug 8;24(1):186. doi: 10.1186/s13075-022-02867-x.
10
Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis.PI3K/Akt/HIF-1α 调控糖酵解在脓毒症中性粒细胞中的免疫作用。
Crit Care. 2022 Jan 28;26(1):29. doi: 10.1186/s13054-022-03893-6.
本文引用的文献
1
Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.凝集素型氧化型低密度脂蛋白受体-1可区分癌症患者中人类多形核髓源性抑制细胞群体。
Sci Immunol. 2016 Aug;1(2). doi: 10.1126/sciimmunol.aaf8943. Epub 2016 Aug 5.
2
Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity.髓系细胞中的精氨酸代谢塑造固有免疫和适应性免疫。
Front Immunol. 2017 Feb 7;8:93. doi: 10.3389/fimmu.2017.00093. eCollection 2017.
3
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview.中性粒细胞胞外诱捕网及其在炎症中的意义：综述
Front Immunol. 2017 Feb 6;8:81. doi: 10.3389/fimmu.2017.00081. eCollection 2017.
4
Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.由mTORC2-IRF4信号轴介导的代谢重编程对巨噬细胞替代性激活至关重要。
Immunity. 2016 Oct 18;45(4):817-830. doi: 10.1016/j.immuni.2016.09.016.
5
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.L-精氨酸调节T细胞代谢并增强其存活及抗肿瘤活性。
Cell. 2016 Oct 20;167(3):829-842.e13. doi: 10.1016/j.cell.2016.09.031. Epub 2016 Oct 13.
6
The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole.NADPH 氧化酶与中性粒细胞的杀菌作用，特别强调吞噬小体中髓过氧化物酶的拟抗菌作用。
Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.MCHD-0018-2015.
7
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.琥珀酸脱氢酶支持线粒体的代谢重编程以驱动炎性巨噬细胞。
Cell. 2016 Oct 6;167(2):457-470.e13. doi: 10.1016/j.cell.2016.08.064. Epub 2016 Sep 22.
8
Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer.癌症中髓源性抑制细胞（MDSC）的代谢重编程
Oncoimmunology. 2016 Jun 27;5(8):e1200771. doi: 10.1080/2162402X.2016.1200771. eCollection 2016 Aug.
9
A guide to immunometabolism for immunologists.免疫学家的免疫代谢指南。
Nat Rev Immunol. 2016 Sep;16(9):553-65. doi: 10.1038/nri.2016.70. Epub 2016 Jul 11.
10
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards.髓系来源抑制细胞命名与鉴定标准的建议。
Nat Commun. 2016 Jul 6;7:12150. doi: 10.1038/ncomms12150.
Zotero 插件