Tang Ranran, Liu Heng, Yuan Yingdi, Xie Kaipeng, Xu Pengfei, Liu Xiaoyun, Wen Juan
Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.
State Key Laboratory of Reproductive Medicine, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Oncotarget. 2017 May 23;8(21):35403-35411. doi: 10.18632/oncotarget.15893.
Although the metabolic syndrome is a commonplace topic, its potential threats to public health is a problem that cannot be neglected. As the living conditions improved significantly over the past few years, the morbidity of metabolic syndrome has also steadily risen, and the onset age is becoming younger. The hepatocellular carcinoma (HCC), is one of the most prevalent life-threatening human cancers worldwide, incidence of which is also on the rise, gradually occupied the top of the list associated with metabolic syndrome related complication. Despite the advanced improvement of HCC management, the lifestyle, environmental factors, obesity, hepatitis B virus (HBV) infection have been recognized as risk factors for the development of liver cancer. In recent years, genetic studies, especially the genome-wide association studies (GWASs) were widely performed, a new era of the human genome research was created, which has significantly promoted the study of complex disease genetics. These progresses have contributed to the discovery of abundant number of genomic loci convincingly linked with complex metabolic feature and HCC. In this review, we briefly summarize the association between metabolic syndrome and HCC, focusing on the genetic factors contributed to metabolic syndrome and HCC.
尽管代谢综合征是一个常见话题，但其对公众健康的潜在威胁却是一个不可忽视的问题。在过去几年中，随着生活条件显著改善，代谢综合征的发病率也稳步上升，且发病年龄正趋于年轻化。肝细胞癌（HCC）是全球最常见的威胁人类生命的癌症之一，其发病率也在上升，逐渐占据与代谢综合征相关并发症的首位。尽管肝癌治疗有了很大进展，但生活方式、环境因素、肥胖、乙型肝炎病毒（HBV）感染已被确认为肝癌发生的危险因素。近年来，遗传研究，尤其是全基因组关联研究（GWASs）广泛开展，开创了人类基因组研究的新时代，极大地推动了复杂疾病遗传学的研究。这些进展有助于发现大量与复杂代谢特征和肝癌有令人信服关联的基因组位点。在本综述中，我们简要总结代谢综合征与肝癌之间的关联，重点关注导致代谢综合征和肝癌的遗传因素。
