Pan Xin-Bin, Huang Shi-Ting, Chen Kai-Hua, Jiang Yan-Ming, Ma Jia-Lin, Qu Song, Li Ling, Chen Long, Zhu Xiao-Dong
Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Oncotarget. 2017 Jul 11;8(28):46211-46218. doi: 10.18632/oncotarget.17582.
Two-dimensional conventional radiotherapy (2D-CRT) and intensity-modulated radiotherapy (IMRT) are effective for control of nasopharyngeal carcinoma (NPC). The purpose of this study was to compare the quality of life (QoL) of stage II NPC patients treated with 2D-CRT versus IMRT. We conducted a cross-sectional study of 106 patients with stage II NPC treated with 2D-CRT (n = 47) versus IMRT (n = 59) between June 2008 and June 2013. For all subjects, disease-free survival was more than 3 years. QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) questions and the Head and Neck 35 (EORTC QLQ-H&N35) questions. Patients receiving IMRT with or without concurrent chemotherapy had better outcomes in head and neck related symptoms and general aspects of QoL than those receiving 2D-CRT with or without concurrent chemotherapy. Thus, IMRT improves the QoL of patients with stage II NPC as compared to 2D-CRT.
二维常规放疗（2D-CRT）和调强放疗（IMRT）对鼻咽癌（NPC）的控制有效。本研究的目的是比较接受2D-CRT与IMRT治疗的II期NPC患者的生活质量（QoL）。我们对2008年6月至2013年6月期间接受2D-CRT（n = 47）与IMRT（n = 59）治疗的106例II期NPC患者进行了横断面研究。所有受试者的无病生存期均超过3年。使用欧洲癌症研究与治疗组织生活质量问卷核心30（EORTC QLQ-C30）问题和头颈35（EORTC QLQ-H&N35）问题评估生活质量。接受IMRT联合或不联合同步化疗的患者在头颈相关症状和生活质量的总体方面比接受2D-CRT联合或不联合同步化疗的患者有更好的结果。因此，与2D-CRT相比，IMRT改善了II期NPC患者的生活质量。
