肿瘤坏死因子对单核细胞趋化活性的重新评估。
Re-evaluation of the chemotactic activity of tumour necrosis factor for monocytes.
作者信息
Wang J M, Walter S, Mantovani A
机构信息
Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy.
出版信息
Immunology. 1990 Nov;71(3):364-7.
Abstract
The present study was designed to re-evaluate the chemotactic activity of recombinant tumour necrosis factor (TNF) and lymphotoxin (LT). TNF and LT induced migration of human monocytes across polycarbonate filter in a 90-min assay. Preincubation with FMLP rendered monocytes unresponsive to subsequent exposure to the same chemoattractant. FMLP-desensitized monocytes retained full responsiveness when exposed to TNF as chemotactic stimulus. The converse was observed when monocytes were deactivated specifically to TNF. FMLP receptor antagonists did not interfere with TNF chemotaxis. A monoclonal anti-TNF antibody inhibited the chemotactic activity of recombinant TNF. These results indicate that, under the experimental conditions utilized here, TNF elicits chemotaxis of human monocytes.
摘要
本研究旨在重新评估重组肿瘤坏死因子（TNF）和淋巴毒素（LT）的趋化活性。在一项90分钟的试验中，TNF和LT诱导人单核细胞穿过聚碳酸酯滤膜迁移。用甲酰甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）预孵育使单核细胞对随后暴露于相同趋化因子无反应。当暴露于TNF作为趋化刺激时，FMLP脱敏的单核细胞保持完全反应性。当单核细胞被特异性地对TNF失活时，观察到相反的情况。FMLP受体拮抗剂不干扰TNF趋化作用。一种单克隆抗TNF抗体抑制重组TNF的趋化活性。这些结果表明，在此处使用的实验条件下，TNF引发人单核细胞的趋化作用。
相似文献
1
Re-evaluation of the chemotactic activity of tumour necrosis factor for monocytes.肿瘤坏死因子对单核细胞趋化活性的重新评估。
Immunology. 1990 Nov;71(3):364-7.
2
Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.肿瘤坏死因子对单核细胞和多形核白细胞具有趋化作用。
J Immunol. 1987 Mar 1;138(5):1469-74.
3
Modulation of human neutrophilic granulocyte functions by recombinant human tumor necrosis factor and recombinant human lymphotoxin. Promotion of adherence, inhibition of chemotactic migration and superoxide anion release from adherent cells.重组人肿瘤坏死因子和重组人淋巴毒素对人嗜中性粒细胞功能的调节。促进黏附，抑制趋化性迁移以及黏附细胞中超氧阴离子的释放。
Clin Exp Immunol. 1988 Oct;74(1):143-8.
4
Induction of monocyte migration by recombinant macrophage colony-stimulating factor.重组巨噬细胞集落刺激因子诱导单核细胞迁移
J Immunol. 1988 Jul 15;141(2):575-9.
5
Tumour necrosis factor-alpha augments the expression of Fc IgE receptor (Fc epsilon RII/CD23) on human monocytic cell lines and down-regulates interleukin-4-driven Fc epsilon RII expression on monocytes.肿瘤坏死因子-α增强人单核细胞系上Fc IgE受体（FcεRII/CD23）的表达，并下调白细胞介素-4驱动的单核细胞上FcεRII的表达。
Immunology. 1993 Mar;78(3):476-81.
6
Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor.通过与重组人肿瘤坏死因子预孵育增强中性粒细胞超氧化物的产生。
J Immunol. 1987 Dec 1;139(11):3783-91.
7
Activation and priming of human monocytes by monocyte chemotactic activating factor: cooperation with other inflammatory cytokines and close association between an increase in cytoplasmic free Ca2+ and intracellular acidification.单核细胞趋化激活因子对人单核细胞的激活与启动：与其他炎性细胞因子的协同作用以及细胞质游离Ca2+增加与细胞内酸化之间的密切关联。
Exp Hematol. 1996 Feb;24(2):169-75.
8
9
引用本文的文献
1
Biomechanical forces enhance directed migration and activation of bone marrow-derived dendritic cells.生物力学力增强了骨髓源性树突状细胞的定向迁移和激活。
Sci Rep. 2021 Jun 8;11(1):12106. doi: 10.1038/s41598-021-91117-2.
2
Non-specific protection from respiratory tract infections in cattle generated by intranasal administration of an innate immune stimulant.经鼻腔给予先天免疫刺激物可对牛产生非特异性呼吸道感染保护作用。
PLoS One. 2020 Jun 25;15(6):e0235422. doi: 10.1371/journal.pone.0235422. eCollection 2020.
3
Effectiveness of a Web-based tailored interactive health communication application for patients with type 2 diabetes or chronic low back pain: randomized controlled trial.基于网络的定制交互式健康交流应用程序对2型糖尿病患者或慢性下背痛患者的有效性：随机对照试验。
J Med Internet Res. 2015 Mar 3;17(3):e53. doi: 10.2196/jmir.3904.
4
Transplantable subcutaneous hepatoma 22a affects functional activity of resident tissue macrophages in periphery.可移植性皮下肝癌22a影响外周组织中常驻巨噬细胞的功能活性。
Int J Cell Biol. 2011;2011:793034. doi: 10.1155/2011/793034. Epub 2011 Jul 3.
5
The effects of interleukin-8 on airway smooth muscle contraction in cystic fibrosis.白细胞介素-8对囊性纤维化患者气道平滑肌收缩的影响。
Respir Res. 2008 Dec 1;9(1):76. doi: 10.1186/1465-9921-9-76.
6
The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFalpha and a TNFalpha 36-62 Peptide.TNF 受体 p55 和 p75 介导 TNFα 和 TNFα 36-62 肽诱导的 PMN 趋化作用。
Mediators Inflamm. 1994;3(5):347-52. doi: 10.1155/S0962935194000487.
7
B-cell involvement in the pathogenesis of RA-is there a contribution of the sympathetic nervous system?B细胞在类风湿性关节炎发病机制中的作用——交感神经系统是否有影响？
Immunol Res. 2008;40(2):148-63. doi: 10.1007/s12026-007-8002-0.
8
In vivo regulation of nitric oxide production by tumor necrosis factor alpha and gamma interferon, but not by interleukin-4, during blood stage malaria in mice.在小鼠血液期疟疾期间，肿瘤坏死因子α和γ干扰素可在体内调节一氧化氮的产生，但白细胞介素-4无此作用。
Infect Immun. 1996 Jan;64(1):44-9. doi: 10.1128/iai.64.1.44-49.1996.
9
Mechanisms of monocyte recruitment and accumulation.单核细胞募集和聚集的机制。
Br Heart J. 1993 Jan;69(1 Suppl):S19-29. doi: 10.1136/hrt.69.1_suppl.s19.
本文引用的文献
1
A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration.一种用于快速准确测量白细胞迁移的48孔微量化学趋化性组件。
J Immunol Methods. 1980;33(3):239-47. doi: 10.1016/0022-1759(80)90211-2.
2
3
Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.肿瘤坏死因子对单核细胞和多形核白细胞具有趋化作用。
J Immunol. 1987 Mar 1;138(5):1469-74.
4
Recombinant human tumor necrosis factor alpha lacks chemotactic activity for human peripheral blood neutrophils and monocytes.
Biochem Biophys Res Commun. 1988 Jun 30;153(3):1223-8. doi: 10.1016/s0006-291x(88)81358-5.
5
Tumoricidal activity of lymphotoxin (tumor necrosis factor beta) in vivo: its effects on macrophages.淋巴毒素（肿瘤坏死因子β）在体内的杀肿瘤活性：其对巨噬细胞的影响。
J Biol Response Mod. 1988 Dec;7(6):619-30.
6
7
Effect of recombinant DNA-produced tumor necrosis factor on various parameters of neutrophil function.重组DNA产生的肿瘤坏死因子对中性粒细胞功能各项参数的影响。
Inflammation. 1988 Aug;12(4):297-309. doi: 10.1007/BF00915767.
8
9
Tumor necrosis, cachexia, shock, and inflammation: a common mediator.肿瘤坏死、恶病质、休克与炎症：一种共同介质。
Annu Rev Biochem. 1988;57:505-18. doi: 10.1146/annurev.bi.57.070188.002445.
10
Chemotactic activity of lymphotoxin and tumour necrosis factor alpha for human neutrophils.淋巴毒素和肿瘤坏死因子α对人中性粒细胞的趋化活性。
Immunology. 1989 Feb;66(2):318-20.
Zotero 插件