Kumar R Kiran, Chandra Sadanandavalli Retnaswami, Kulkarni Girish B, Bharath Rose Dawn
Department of Neurophysician, Yasoda Hospital, Hyderabad, Telangana, India.
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Indian J Psychol Med. 2017 Mar-Apr;39(2):122-130. doi: 10.4103/0253-7176.203119.
To study electroencephalography (EEG) changes in patients with cortical dementias (Alzheimer's disease [AD] and frontotemporal dementia (FTD). (1) To correlate EEG changes with clinical severity of dementia as assessed by rating scales. (2) To correlate global gray matter volume (GGMV) with EEG scores and clinical severity rating scales.
This is a prospective cross-sectional study involving patients fulfilling the criteria for Probable AD and FTD. A total of thirty patients (20 = FTD, 10 = AD) underwent detailed neuropsychological evaluation, dementia rating scales, EEG, and magnetic resonance imaging. Five EEG parameters were acquired and each parameter is scaled and the total score was compared with neuropsychological parameters and GGMV.
For FTD, the mean age of patients was 58.85 ± 6.87, mean mini-mental state examination score was 13.30 ± 6.33, Hindi mental state examination: 14.35 ± 6.28, mean grant total EEG score (GTES): 7.80 ± 5.39, and mean GGMV: 464580.76 ± 52127 mm and for AD, the same were 69.50 ± 8.59, 12.90 ± 5.56, 14.20 ± 5.31, 9.80 ± 5.29, and 483208 ± 47371.5 mm, respectively. GTES for mild, moderate, and severe FTD are 2.33 ± 1.528, 6.00 ± 3.162, and 10.70 ± 5.677 and for AD it is 4, 7.50 ± 4.041, 15 ± 1.414, respectively. The GGMV for mild, moderate, and severe FTD was 511836 ± 45005, 492693.1 ± 50624, and 430725 ± 30744 and for AD it is 527217.3 ± 36171, 503598 ± 3006, and 440812 ± 33911.
The most common EEG abnormalities in cortical dementias are reduced frequency of rhythmic background activity. There is a significant correlation between GTES and dementia severity and global gray matter volume but the proportional correlation with GTES and volumetric scores is not significant.
EEG is a cheap and sensitive and easily available tool to assess disease severity in patients with cortical dementias and thus helps in planning the type of rehabilitatory interventions and prognostication.
研究皮质性痴呆（阿尔茨海默病[AD]和额颞叶痴呆[FTD]）患者的脑电图（EEG）变化。（1）将EEG变化与通过评定量表评估的痴呆临床严重程度相关联。（2）将全脑灰质体积（GGMV）与EEG评分及临床严重程度评定量表相关联。
这是一项前瞻性横断面研究，纳入符合可能AD和FTD标准的患者。总共30例患者（20例=FTD，10例=AD）接受了详细的神经心理学评估、痴呆评定量表、EEG和磁共振成像检查。获取了5个EEG参数，每个参数进行了评分，总分与神经心理学参数及GGMV进行比较。
对于FTD，患者的平均年龄为58.85±6.87岁，平均简易精神状态检查表评分为13.30±6.33，印地语精神状态检查表评分为14.35±6.28，平均总EEG评分（GTES）为7.80±5.39，平均GGMV为464580.76±52127立方毫米；对于AD，相应数据分别为69.50±8.59岁、12.90±5.56、14.20±5.31、9.80±5.29和483208±47371.5立方毫米。轻度、中度和重度FTD的GTES分别为2.33±1.528、6.00±3.162和10.70±5.677，AD的分别为4、7.50±4.041、15±1.414。轻度、中度和重度FTD的GGMV分别为511836±45005、492693.1±50624和430725±30744，AD的分别为527217.3±36171、503598±3006和440812±33911。
皮质性痴呆最常见的EEG异常是节律性背景活动频率降低。GTES与痴呆严重程度和全脑灰质体积之间存在显著相关性，但GTES与体积评分的比例相关性不显著。
EEG是一种廉价、敏感且易于获得的工具，可用于评估皮质性痴呆患者的疾病严重程度，从而有助于规划康复干预类型和进行预后评估。
