Rodriguez G, Nobili F, Arrigo A, Priano F, De Carli F, Francione S, Gambaro M, Rosadini G
Department of Motor Sciences (Neurophysiopathology), University of Genova, Italy.
Electroencephalogr Clin Neurophysiol. 1996 Aug;99(2):123-8. doi: 10.1016/0013-4694(96)95723-5.
In 31 Alzheimer outpatients followed up for a mean time of 26.4 months the hypothesis that quantitative electroencephalography (qEEG) could predict the loss of activities of daily living (ADL), the onset of incontinence, and death was tested by the Weibull proportional hazard model of 'lifereg' procedure of the Statistical Analysis System package. A central-posterior temporal region was considered in either side (power-weighted, log transformed relative values). Right delta predicted both the loss of ADL and death, whereas right theta predicted the onset of incontinence. Left values gave borderline significant results toward all end-points, whereas power-weighted mean frequency always gave borderline results. The curves calculated for predicted times may be a valid support for the clinician in attempting prognostic judgments of disease evolution.
在31名平均随访26.4个月的阿尔茨海默病门诊患者中，使用统计分析系统软件包“lifereg”程序的威布尔比例风险模型，对定量脑电图（qEEG）能否预测日常生活活动能力丧失（ADL）、失禁的发生以及死亡这一假设进行了检验。双侧均考虑中央后颞区（功率加权、对数转换后的相对值）。右侧δ波预测了ADL能力丧失和死亡，而右侧θ波预测了失禁的发生。左侧数值对所有终点均给出临界显著结果，而功率加权平均频率始终给出临界结果。为预测时间计算的曲线可能为临床医生尝试对疾病进展进行预后判断提供有效的支持。
