Rae-Grant A, Blume W, Lau C, Hachinski V C, Fisman M, Merskey H
Arch Neurol. 1987 Jan;44(1):50-4. doi: 10.1001/archneur.1987.00520130042015.
As part of a longitudinal cohort study of dementia, 139 patients with Alzheimer's disease (dementia of the Alzheimer type, senile dementia of the Alzheimer type, and mixed type [ischemic score, 4 to 7]) and 148 age-matched control subjects were evaluated for electroencephalographic (EEG) abnormalities and their evolution. Electroencephalograms were significantly different in the two groups; EEGs worsened overall in the two groups during a period of one to four years, but most subjects showed no alteration in their EEGs. Some patients showed improvement in their EEG findings during the follow-up period. A strong correlation between EEG grade and psychometric scores was consistently found over sequential studies. In a subgroup of patients on whom autopsies were performed, morphometric neuron loss correlated significantly with EEG severity.
作为一项痴呆症纵向队列研究的一部分，对139例阿尔茨海默病患者（阿尔茨海默型痴呆、老年性阿尔茨海默型痴呆和混合型[缺血评分，4至7]）和148例年龄匹配的对照受试者进行了脑电图（EEG）异常及其演变情况的评估。两组的脑电图有显著差异；在一至四年的时间里，两组的脑电图总体上都有所恶化，但大多数受试者的脑电图没有变化。一些患者在随访期间脑电图结果有所改善。在连续的研究中，始终发现脑电图分级与心理测量分数之间存在很强的相关性。在进行尸检的患者亚组中，形态学神经元丢失与脑电图严重程度显著相关。
