Robinson D J, Merskey H, Blume W T, Fry R, Williamson P C, Hachinski V C
Department of Research, London Psychiatric Hospital, Ontario.
Arch Neurol. 1994 Mar;51(3):280-4. doi: 10.1001/archneur.1994.00540150074020.
To determine the usefulness or otherwise of the awake electroencephalogram (EEG) in the diagnosis of Alzheimer's disease (AD).
Prospective collection of one or more awake EEGs in patients diagnosed as having AD or mixed AD and multi-infarct dementia according to current systematic criteria with analysis of those cases confirmed by postmortem examination. Systematized blind interpretation of EEGs.
Tertiary care practice with both ambulatory and hospitalized patients, ie, neurological department in general hospital and psychogeriatric unit in psychiatric hospital.
A series of 86 subjects with AD and 17 with mixed AD and multi-infarct dementia being those members of a consecutive series on whom postmortem information was available. Awake EEGs in 56 age- and sex-matched control subjects.
Seventy-five patients with AD (87.2%) and 13 of the mixed group (76.5%) had abnormal EEGs on first testing, giving a sensitivity of 87.2% for uncomplicated AD. Ultimately, 79 (92%) of 86 patients with AD had abnormal EEGs. Twenty (35%) of 56 EEGs for matching control subjects were abnormal. Moderately abnormal or severely abnormal EEGs were found in 10 (50%) of 20 of the patients with AD of less than 4 year's duration compared with two (4.1%) of 49 of the control subjects, giving a specificity of 95.9% for EEGs with this degree of abnormality. The normal EEG had a negative predictive value of 0.825 with respect to the diagnosis of AD in these populations.
Widespread availability, low cost, and high sensitivity support the use of the awake EEG in the diagnosis of AD.
确定清醒脑电图（EEG）在阿尔茨海默病（AD）诊断中的有用性。
根据当前系统标准，前瞻性收集被诊断为患有AD或AD合并多发梗死性痴呆患者的一次或多次清醒EEG，并对经尸检证实的病例进行分析。对EEG进行系统化盲法解读。
为三级医疗实践，涉及门诊和住院患者，即综合医院的神经科和精神病医院的老年精神科。
一系列86例AD患者和17例AD合并多发梗死性痴呆患者，这些患者是连续系列中可获得尸检信息的成员。56名年龄和性别匹配的对照受试者的清醒EEG。
75例AD患者（87.2%）和混合组中的13例（76.5%）在首次检测时EEG异常，单纯AD的敏感性为87.2%。最终，86例AD患者中有79例（92%）EEG异常。56例对照受试者的EEG中有20例（35%）异常。病程小于4年的AD患者中，20例中有10例（50%）EEG为中度异常或重度异常，而对照受试者49例中有2例（4.1%），EEG达到这种异常程度时的特异性为95.9%。在这些人群中，正常EEG对AD诊断的阴性预测值为0.825。
广泛可用性、低成本和高敏感性支持清醒EEG用于AD的诊断。
