Bologna Matteo, Berardelli Alfredo
Department of Neurology and Psychiatry and Neuromed Institute, Sapienza University of Rome, Viale dell'Università, 30, 00185 Rome, Italy.
Neuromed Institute IRCCS, Pozzilli, IS Italy.
Cerebellum Ataxias. 2017 May 12;4:6. doi: 10.1186/s40673-017-0064-8. eCollection 2017.
Dystonia is a movement disorder that is characterized by involuntary muscle contractions, abnormal movements and postures, as well as by non-motor symptoms, and is due to abnormalities in different brain areas. In this article, we focus on the growing number of experimental studies aimed at explaining the pathophysiological role of the cerebellum in dystonia. Lastly, we highlight gaps in current knowledge and issues that future research studies should focus on as well as some of the potential applications of this research avenue. Clarifying the pathophysiological role of cerebellum in dystonia is an important concern given the increasing availability of invasive and non-invasive stimulation techniques and their potential therapeutic role in this condition.
肌张力障碍是一种运动障碍，其特征为不自主肌肉收缩、异常运动和姿势以及非运动症状，病因是不同脑区的异常。在本文中，我们重点关注越来越多旨在解释小脑在肌张力障碍中的病理生理作用的实验研究。最后，我们强调了当前知识的空白以及未来研究应关注的问题，以及这一研究途径的一些潜在应用。鉴于侵入性和非侵入性刺激技术的可用性不断增加及其在这种疾病中的潜在治疗作用，阐明小脑在肌张力障碍中的病理生理作用是一个重要问题。
