Mukai Junichi, Tsuge Yuta, Yamada Michiko, Otori Katsuya, Atsuda Koichiro
Laboratory of Clinical Pharmacy Education, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641 Japan.
Laboratory of Pharmacy Practice and Science I, 1-15-1, Kitasato, Minami-Ku, Sagamihara, Kanagawa 252-0375 Japan.
J Pharm Health Care Sci. 2017 May 16;3:15. doi: 10.1186/s40780-017-0084-9. eCollection 2017.
Randomized controlled trials (RCTs) reported that resistant dextrin (RD) exerted pleiotropic effects on humans. However, limited information is available on the effects of RD for weight loss. We conducted a systematic review with a meta-analysis to summarize the available literature and compare the efficacy of RD for weight loss with that of a placebo in overweight adults.
We searched the electronic databases MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, Web of Science, ClincalTrials.gov, and Japana Centra Revuo Medicina (Ichushi-web) for studies from their onset to November 2016, and there was no language restriction. Trials were included if they were RCTs (1) comparing the effects of RD with a placebo in adults (18 years or older), (2) reporting body mass index, and (3) including overweight/obese subjects as defined by the authors of RCTs. The weighted mean difference with a 95% confidence interval (CI) was calculated using a random-effects model.
Of the 484 studies retrieved, 3 RCTs involving 275 subjects were included in our review. The durations of RCTs ranged between 8 and 12 weeks. All RCTs were conducted in Asian countries. RD significantly improved body mass index [mean difference -0.39 (95% CI -0.57 to -0.21) kg/m, < 0.01] and body weight [mean difference -0.81 (95% CI -0.93 to -0.69) kg, < 0.01] in overweight adults.
Our review suggests that RD exerts beneficial effects for weight loss in overweight adults. More RCTs with different populations and longer follow-ups are needed in order to confirm that supplementation with RD has beneficial effects for weight loss in overweight adults. We consider this review to provide important information for the future submission of food with health claims.
随机对照试验（RCT）报告称，抗性糊精（RD）对人体具有多种效应。然而，关于RD对体重减轻影响的信息有限。我们进行了一项系统评价和荟萃分析，以总结现有文献，并比较RD与安慰剂对超重成年人减肥的疗效。
我们检索了电子数据库MEDLINE、EMBASE、Cochrane对照试验中央注册库（CENTRAL）、CINAHL、科学网、ClinicalTrials.gov和日本医学中央杂志（Ichushi-web），检索时间从各数据库建库至2016年11月，无语言限制。纳入的试验需为RCT：（1）比较RD与安慰剂对成年人（18岁及以上）的影响；（2）报告体重指数；（3）纳入RCT作者定义的超重/肥胖受试者。采用随机效应模型计算加权平均差及95%置信区间（CI）。
在检索到的484项研究中，我们的评价纳入了3项涉及275名受试者的RCT。RCT的持续时间为8至12周。所有RCT均在亚洲国家进行。RD显著改善了超重成年人的体重指数[平均差-0.39（95%CI-0.57至-0.21）kg/m²，P＜0.01]和体重[平均差-0.81（95%CI-0.93至-0.69）kg，P＜0.01]。
我们的评价表明，RD对超重成年人减肥具有有益作用。需要更多针对不同人群且随访时间更长的RCT，以证实补充RD对超重成年人减肥具有有益作用。我们认为该评价为未来提交具有健康声称的食品提供了重要信息。
