Tongji University Medical College, Institute of Nutrition, Health and Food, 1239 Siping Road, Shanghai, China.
Appl Physiol Nutr Metab. 2010 Dec;35(6):773-82. doi: 10.1139/H10-074.
The influence of dietary fiber on determinants of metabolic syndrome is controversial. The objective of this study was to determine the effects of NUTRIOSE supplementation on insulin resistance and the determinants of metabolic syndrome in overweight men. In this double-blind, randomized, placebo-controlled study, we supplemented the diets of overweight Chinese men with 250 mL of fruit juice that contained NUTRIOSE (Test group: n = 60, age = 30.4 ± 4.3 years, body mass index (BMI) = 24.5 ± 0.2 kg·m-2) or a maltodextrin placebo (
n = 60, age = 31.6 ± 4.1 years, BMI = 24.5 ± 0.3 kg·m-2) at a dosage of 17 g twice daily for 12 weeks. Daily caloric intake, body composition, blood chemistry, and blood pressure were evaluated every 4 weeks during the trial. Test subjects consumed fewer calories per day and had greater reductions in body weight, BMI, body fat percentage, and waist circumference than Control subjects. All markers of glucose metabolism improved in the Test group, with increases in adiponectin and reductions in glucose, insulin, homeostasis model assessment-estimated insulin resistance, glycosylated hemoglobin, and glycated albumin (all p < 0.01). Similarly, all lipid measures improved with increases in high-density lipoprotein cholesterol and reductions in total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglycerides (all p < 0.01). No changes were observed in systolic blood pressure between groups. Most components of glucose metabolism and the lipid profile were significantly better in the Test than in the Control subjects. No adverse events or gastrointestinal complaints were reported in either group. Supplementation with NUTRIOSE for 12 weeks is well tolerated, lowers insulin resistance, and improves determinants of metabolic syndrome in overweight men.
本研究旨在确定 NUTRIOSE 补充剂对超重男性胰岛素抵抗和代谢综合征决定因素的影响。
这是一项双盲、随机、安慰剂对照研究，我们向超重的中国男性补充含有 NUTRIOSE 的果汁（试验组：n = 60，年龄 = 30.4 ± 4.3 岁，体重指数（BMI）= 24.5 ± 0.2 kg·m-2）或麦芽糊精安慰剂（对照组：n = 60，年龄 = 31.6 ± 4.1 岁，BMI = 24.5 ± 0.3 kg·m-2），剂量为每天 17 克，每天两次，持续 12 周。试验期间，每 4 周评估一次每日热量摄入、身体成分、血液化学和血压。
与对照组相比，试验组每天摄入的热量更少，体重、BMI、体脂百分比和腰围的降低幅度更大。所有葡萄糖代谢标志物均得到改善，脂联素增加，血糖、胰岛素、稳态模型评估-估计的胰岛素抵抗、糖化血红蛋白和糖化白蛋白降低（均 p < 0.01）。同样，所有血脂指标均得到改善，高密度脂蛋白胆固醇增加，总胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇和甘油三酯降低（均 p < 0.01）。两组间收缩压无变化。试验组的葡萄糖代谢和血脂谱的大多数成分均明显优于对照组。两组均未报告不良事件或胃肠道投诉。
12 周补充 NUTRIOSE 可耐受良好，降低胰岛素抵抗，并改善超重男性代谢综合征的决定因素。
