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老年非ST段抬高型急性冠状动脉综合征患者的管理

Management of elderly patients with a non-ST-segment-elevation acute coronary syndrome.

作者信息

Gimbel M E, Ten Berg J M

机构信息

Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.

出版信息

Neth Heart J. 2017 Jul;25(7-8):409-415. doi: 10.1007/s12471-017-1002-3.

DOI:10.1007/s12471-017-1002-3
PMID:28516369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5513990/
Abstract

Elderly patients with an acute coronary syndrome are underrepresented in randomised controlled trials. Neither the European Society of Cardiology nor the American Heart Association/American College of Cardiology acute coronary syndrome guidelines provide specific recommendations for elderly patients. However, elderly patients are at higher thrombotic and bleeding risk compared with younger patients leading to difficulties in choosing the optimal treatment. In this review, we discuss the uncertainties we encounter in treating elderly patients with non-ST-elevation acute coronary syndrome and suggest treatment options based on the existing literature.

摘要

老年急性冠状动脉综合征患者在随机对照试验中的代表性不足。欧洲心脏病学会和美国心脏协会/美国心脏病学会的急性冠状动脉综合征指南均未针对老年患者提供具体建议。然而,与年轻患者相比,老年患者的血栓形成和出血风险更高,这导致在选择最佳治疗方案时存在困难。在本综述中,我们讨论了在治疗非ST段抬高型急性冠状动脉综合征老年患者时遇到的不确定性,并根据现有文献提出了治疗选择。

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本文引用的文献

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Prasugrel Versus Ticagrelor in Patients With Acute Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention: Multicenter Randomized PRAGUE-18 Study.普拉格雷与替格瑞洛在经皮冠状动脉介入治疗的急性心肌梗死患者中的应用:多中心随机 PRAGUE-18 研究。
Circulation. 2016 Nov 22;134(21):1603-1612. doi: 10.1161/CIRCULATIONAHA.116.024823. Epub 2016 Aug 30.
2
Frailty predicts major bleeding within 30days in elderly patients with Acute Coronary Syndrome.衰弱可预测老年急性冠状动脉综合征患者30天内的大出血。
Int J Cardiol. 2016 Nov 1;222:590-593. doi: 10.1016/j.ijcard.2016.07.268. Epub 2016 Aug 1.
3
Combined Use of Bivalirudin and Radial Access in Acute Coronary Syndromes Is Not Superior to the Use of Either One Separately: Meta-Analysis of Randomized Controlled Trials.比伐卢定联合桡动脉入路与单独使用比伐卢定或桡动脉入路治疗急性冠状动脉综合征的疗效比较:随机对照试验的荟萃分析。
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Randomized comparison between the invasive and conservative strategies in comorbid elderly patients with non-ST elevation myocardial infarction.非 ST 段抬高型心肌梗死合并症老年患者侵入性与保守性策略的随机比较。
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