Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02115, USA.
Curr Neurol Neurosci Rep. 2017 Jul;17(7):53. doi: 10.1007/s11910-017-0760-z.
Neuroimaging plays a critical role in diagnosis of brain tumors and in assessment of response to therapy. However, challenges remain, including accurately and reproducibly assessing response to therapy, defining endpoints for neuro-oncology trials, providing prognostic information, and differentiating progressive disease from post-therapeutic changes particularly in the setting of antiangiogenic and other novel therapies.
Recent advances in the imaging of brain tumors include application of advanced MRI imaging techniques to assess tumor response to therapy and analysis of imaging features correlating to molecular markers, grade, and prognosis. This review aims to summarize recent advances in imaging as applied to current diagnostic and therapeutic neuro-oncologic challenges.
神经影像学在脑肿瘤的诊断和治疗反应评估中起着关键作用。然而,仍存在一些挑战,包括准确和可重复地评估治疗反应、定义神经肿瘤学试验的终点、提供预后信息,以及区分进行性疾病与治疗后变化,特别是在抗血管生成和其他新疗法的情况下。
脑肿瘤成像的最新进展包括应用先进的 MRI 成像技术来评估肿瘤对治疗的反应,以及分析与分子标志物、分级和预后相关的成像特征。本综述旨在总结成像方面的最新进展,以应对当前神经肿瘤学诊断和治疗的挑战。