Dhayabaran V Violet, Prakash T Daniel
PG and Research Department of Chemistry, Bishop Heber College, Tiruchirappalli, India.
Luminescence. 2017 Nov;32(7):1339-1348. doi: 10.1002/bio.3330. Epub 2017 May 18.
A novel Schiff base, (S,Z)-4-(methylthio)-2-((3-oxo-2,3-dihydro-1H-inden-1-ylidene)amino)butanoic acid (L) and four M(II) complexes (where M = Co, Cu, Ni and Zn) were synthesized and characterized. The DNA-binding characteristics of the complexes were investigated using various spectroscopic methods and viscosity measurements. Analysis of the results suggests that all the complexes bind to calf thymus DNA via intercalation. Among the four, Cu(II) complex was found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm. These complexes also exhibit good antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl radical. In vitro antibacterial and antifungal assay indicates that these complexes are good antimicrobial agents.
合成并表征了一种新型席夫碱，即(S,Z)-4-(甲硫基)-2-((3-氧代-2,3-二氢-1H-茚-1-亚基)氨基)丁酸(L)以及四种M(II)配合物（其中M = Co、Cu、Ni和Zn）。使用各种光谱方法和粘度测量研究了配合物的DNA结合特性。结果分析表明，所有配合物均通过嵌入作用与小牛胸腺DNA结合。在这四种配合物中，发现Cu(II)配合物在365 nm照射下能促进质粒DNA pBR322的光裂解。这些配合物对2,2-二苯基-1-苦基肼自由基也表现出良好的抗氧化活性。体外抗菌和抗真菌试验表明，这些配合物是良好的抗菌剂。
