Department of Radiological Sciences, University of California, Los Angeles, California, USA.
Biomedical Physics Interdepartmental Program, University of California, Los Angeles, California, USA.
Magn Reson Med. 2018 Feb;79(2):654-662. doi: 10.1002/mrm.26705. Epub 2017 May 17.
To evaluate a technique for simultaneous quantitative T and apparent diffusion coefficient (ADC) mapping in the heart (T +ADC) using spin echo (SE) diffusion-weighted imaging (DWI).
T maps from T +ADC were compared with single-echo SE in phantoms and with T -prepared (T -prep) balanced steady-state free precession (bSSFP) in healthy volunteers. ADC maps from T +ADC were compared with conventional DWI in phantoms and in vivo. T +ADC was also demonstrated in a patient with acute myocardial infarction (MI).
Phantom T values from T +ADC were closer to a single-echo SE reference than T -prep bSSFP (-2.3 ± 6.0% vs 22.2 ± 16.3%; P < 0.01), and ADC values were in excellent agreement with DWI (0.28 ± 0.4%). In volunteers, myocardial T values from T +ADC were significantly shorter than T -prep bSSFP (35.8 ± 3.1 vs 46.8 ± 3.8 ms; P < 0.01); myocardial ADC was not significantly (N.S.) different between T +ADC and conventional motion-compensated DWI (1.39 ± 0.18 vs 1.38 ± 0.18 mm /ms; P = N.S.). In the patient, T and ADC were both significantly elevated in the infarct compared with remote myocardium (T : 40.4 ± 7.6 vs 56.8 ± 22.0; P < 0.01; ADC: 1.47 ± 0.59 vs 1.65 ± 0.65 mm /ms; P < 0.01).
T +ADC generated coregistered, free-breathing T and ADC maps in healthy volunteers and a patient with acute MI with no cost in accuracy, precision, or scan time compared with DWI. Magn Reson Med 79:654-662, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
利用自旋回波（SE）扩散加权成像（DWI）评估心脏（T+ADC）中同时定量 T 值和表观扩散系数（ADC）的技术。
在体模和健康志愿者中，分别比较 T+ADC 的 T 图与单回波 SE 图、T 准备（T-prep）平衡稳态自由进动（bSSFP）图；比较 T+ADC 的 ADC 图与体模和体内常规 DWI。还在一位急性心肌梗死（MI）患者中展示了 T+ADC。
T+ADC 的体模 T 值比 T-prep bSSFP 更接近单回波 SE 参考值（-2.3±6.0%比 22.2±16.3%；P<0.01），并且 ADC 值与 DWI 非常吻合（0.28±0.4%）。在志愿者中，T+ADC 的心肌 T 值明显短于 T-prep bSSFP（35.8±3.1 比 46.8±3.8 ms；P<0.01）；T+ADC 和常规运动补偿 DWI 之间的心肌 ADC 无显著差异（N.S.）（1.39±0.18 比 1.38±0.18 mm /ms；P=N.S.）。在患者中，与远隔心肌相比，梗死区的 T 和 ADC 均显著升高（T：40.4±7.6 比 56.8±22.0；P<0.01；ADC：1.47±0.59 比 1.65±0.65 mm /ms；P<0.01）。
与 DWI 相比，T+ADC 在健康志愿者和一位急性 MI 患者中生成了配准的、自由呼吸的 T 和 ADC 图，并且在准确性、精密度或扫描时间方面没有成本。磁共振医学 79:654-662, 2018. © 2017 国际磁共振学会。
