Ma Shuo, Jiang Yue, Huang Weiting, Li Xintao, Li Shuzhuang
Department of Physiology, Dalian Medical University, Dalian, Liaoning, China (mainland).
The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (mainland).
Med Sci Monit. 2017 May 18;23:2340-2347. doi: 10.12659/msm.901920.
Heart transplantation has evolved as the criterion standard therapy for end-stage heart failure, but its efficacy is limited by the development of cardiac allograft vasculopathy (CAV), a unique and rapidly progressive form of atherosclerosis in heart transplant recipients. Here, we briefly review the key processes in the development of CAV during heart transplantation and highlight the roles of transient receptor potential (TRP) channels in these processes during heart transplantation. Understanding the roles of TRP channels in contributing to the key procedures for the development of CAV during heart transplantation could provide basic scientific knowledge for the development of new preventive and therapeutic approaches to manage patients with CAV after heart transplantation.
心脏移植已发展成为终末期心力衰竭的标准治疗方法，但其疗效受到心脏移植血管病变（CAV）的限制，CAV是心脏移植受者中一种独特且进展迅速的动脉粥样硬化形式。在此，我们简要回顾心脏移植过程中CAV发生发展的关键过程，并强调瞬时受体电位（TRP）通道在心脏移植这些过程中的作用。了解TRP通道在心脏移植期间CAV发生发展关键过程中的作用，可为开发新的预防和治疗方法提供基础科学知识，以管理心脏移植后患有CAV的患者。
