Lovato A, Restivo D A, Ottaviano G, Marioni G, Marchese-Ragona R
Department of Neuroscience DNS, University of Padova, Audiology Unit at Treviso Hospital, Treviso, Italy.
Department of Internal Medicine, Neurologic Unit, Nuovo "Garibaldi" Hospital, Catania, Italy.
Acta Otorhinolaryngol Ital. 2017 Apr;37(2):168-171. doi: 10.14639/0392-100X-1608.
Botulinum toxin (BTX) is a neurotoxic protein produced by Clostridium botulinum, an anaerobic bacterium. BTX therapy is a safe and effective treatment when used for functional silencing of the salivary glands in disorders such as sialoceles and salivary fistulae that may have a post-traumatic or post-operative origin. BTX injections can be considered in sialoceles and salivary fistulae after the failure of or together with conservative treatments (e.g. antibiotics, pressure dressings, or serial aspirations). BTX treatment has a promising role in chronic sialadenitis. BTX therapy is highly successful in the treatment of gustatory sweating (Frey's syndrome), and could be considered the gold standard treatment for this neurological disorder.
肉毒杆菌毒素（BTX）是由厌氧细菌肉毒梭菌产生的一种神经毒性蛋白。当用于功能性抑制唾液腺时，BTX疗法是一种安全有效的治疗方法，可用于治疗诸如涎囊肿和唾液瘘等可能有创伤后或术后病因的疾病。在涎囊肿和唾液瘘经保守治疗（如抗生素、加压敷料或反复抽吸）失败后或与保守治疗联合使用时，可考虑注射BTX。BTX治疗在慢性涎腺炎中具有广阔前景。BTX疗法在治疗味觉性出汗（弗雷综合征）方面非常成功，可被视为这种神经疾病的金标准治疗方法。
