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A型肉毒杆菌神经毒素治疗腮腺瘘和味觉出汗综合征

Management of parotid fistula and Frey's syndrome with Botulinum neurotoxin type A.

作者信息

Chowdhury Ripon, Roy Dev, Roy Abhimanyu

机构信息

Department of Oral and Maxillofacial Pathology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India.

Department of ENT, Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, West Bengal, India.

出版信息

Natl J Maxillofac Surg. 2021 Jan-Apr;12(1):106-108. doi: 10.4103/njms.NJMS_72_20. Epub 2021 Mar 16.

DOI:10.4103/njms.NJMS_72_20
PMID:34188411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8191560/
Abstract

The common cause of parotid fistula is parotid gland surgery and is frequently due to injury to the gland rather than to the duct. The frequency of postparotidectomy fistula is 14%. Other causes include facial trauma, congenital anomalies of the parotid gland, malignancies originating from the parotid gland and infections. Although there are several options for the treatment of parotid fistula and Frey's syndrome, very few treatment options are deemed optimal. The use of Botulinum A neurotoxin as a conservative method of treatment for parotid fistula and Frey's syndrome is a recent and evolving concept.

摘要

腮腺瘘的常见病因是腮腺手术，且常常是由于腺体损伤而非导管损伤所致。腮腺切除术后瘘的发生率为14%。其他病因包括面部创伤、腮腺先天性异常、源自腮腺的恶性肿瘤及感染。尽管治疗腮腺瘘和 Frey 综合征有多种选择，但很少有治疗方案被认为是最佳的。使用A型肉毒杆菌神经毒素作为腮腺瘘和 Frey 综合征的保守治疗方法是一个新出现且不断发展的概念。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b8/8191560/8fcc6aefbdb2/NJMS-12-106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b8/8191560/8ac67c1b2bbd/NJMS-12-106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b8/8191560/8fcc6aefbdb2/NJMS-12-106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b8/8191560/8ac67c1b2bbd/NJMS-12-106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b8/8191560/8fcc6aefbdb2/NJMS-12-106-g002.jpg

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本文引用的文献

1
Botulinum toxin therapy: functional silencing of salivary disorders.肉毒杆菌毒素疗法：唾液腺疾病的功能沉默
Acta Otorhinolaryngol Ital. 2017 Apr;37(2):168-171. doi: 10.14639/0392-100X-1608.
2
Auriculotemporal Syndrome (Frey Syndrome).耳颞综合征（弗雷综合征）。
Otolaryngol Clin North Am. 2016 Apr;49(2):501-9. doi: 10.1016/j.otc.2015.10.010. Epub 2016 Feb 20.
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Efficacy and safety of botulinum toxin type A for treatment of Frey's syndrome: evidence from 22 published articles.A型肉毒杆菌毒素治疗味觉性出汗综合征的疗效与安全性：来自22篇已发表文章的证据
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Fistulectomy of the parotid fistula secondary to suppurative parotitis: a case report.化脓性腮腺炎继发腮腺瘘的瘘管切除术：一例报告
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5
Botulinum toxin treatment of salivary fistulas following parotidectomy: follow-up results.腮腺切除术后唾液瘘的肉毒杆菌毒素治疗：随访结果
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Head Neck. 2013 Jan;35(1):E11-2. doi: 10.1002/hed.21778. Epub 2011 Jun 17.
9
[The incidence of Frey syndrome following parotidectomy: results of a survey and follow-up].[腮腺切除术后味觉出汗综合征的发生率：一项调查及随访结果]
HNO. 2011 Feb;59(2):173-8. doi: 10.1007/s00106-010-2223-6.
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Botulinum toxin.肉毒杆菌毒素
Indian J Dermatol. 2010;55(1):8-14. doi: 10.4103/0019-5154.60343.