Billington Emma O, Gamble Greg D, Bristow Sarah, Reid Ian R
Bone & Joint Research Group, University of Auckland, Auckland, New Zealand.
Division of Endocrinology & Metabolism, University of Calgary, Calgary, AB, Canada.
Eur J Clin Invest. 2017 Jul;47(7):486-493. doi: 10.1111/eci.12769. Epub 2017 Jun 13.
Inorganic phosphate is a crucial component of cellular energy metabolism. We have identified an inverse relationship between serum phosphate concentration and fat mass in a cohort of healthy men. This study reports those data and determines whether this association is present in two female populations.
Cross-sectional data from three independent cohorts, consisting of healthy adult males (Male Cohort, n = 323) and healthy postmenopausal women (Female Cohort 1, n = 185; and Female Cohort 2, n = 1471), are reported. Associations between serum phosphate and weight, body mass index (BMI), fat mass and bone mineral density (BMD) were assessed. In a fourth cohort of postmenopausal women (FGF23 Cohort, n = 20), associations between fibroblast growth factor 23 (FGF23), weight and BMI were assessed.
Serum phosphate correlated inversely with weight, BMI and fat mass across all three cohorts (r = -0·13 to -0·31, P < 0·0001-0·02). Associations were diminished after adjustment for PTH, but remained significant. In the FGF23 Cohort, FGF23 was positively correlated with weight (r = 0·60, P = 0·007) and BMI (r = 0·49, P = 0·03). Phosphate was inversely associated with BMD in Female Cohorts 1 and 2 (r = -0·08 to -0·29, P < 0·0001-0·02). This relationship was attenuated, but remained significant at most sites, following adjustment for age, fat mass, renal function and 25-hydroxyvitamin D.
Serum phosphate is inversely associated with measures of adiposity in both women and men, largely independently of PTH. FGF23 might mediate these associations. This relationship may be an unrecognized confounder in some of the correlates of serum phosphate already described.
无机磷酸盐是细胞能量代谢的关键组成部分。我们在一组健康男性中发现血清磷酸盐浓度与脂肪量之间呈负相关。本研究报告了这些数据，并确定这种关联是否存在于两个女性群体中。
报告了来自三个独立队列的横断面数据，包括健康成年男性（男性队列，n = 323）和健康绝经后女性（女性队列1，n = 185；女性队列2，n = 1471）。评估了血清磷酸盐与体重、体重指数（BMI）、脂肪量和骨矿物质密度（BMD）之间的关联。在第四组绝经后女性（FGF23队列，n = 20）中，评估了成纤维细胞生长因子23（FGF23）、体重和BMI之间的关联。
在所有三个队列中，血清磷酸盐与体重、BMI和脂肪量呈负相关（r = -0·13至-0·31，P < 0·0001 - 0·02）。在调整甲状旁腺激素（PTH）后，这种关联减弱，但仍然显著。在FGF23队列中，FGF23与体重（r = 0·60，P = 0·007）和BMI（r = 0·49，P = 0·03）呈正相关。在女性队列1和2中，磷酸盐与BMD呈负相关（r = -0·08至-0·29，P < 0·0001 - 0·02）。在调整年龄、脂肪量、肾功能和25-羟维生素D后，这种关系减弱，但在大多数部位仍然显著。
血清磷酸盐与女性和男性的肥胖指标呈负相关，在很大程度上独立于PTH。FGF23可能介导了这些关联。这种关系可能是一些已描述的血清磷酸盐相关因素中未被认识的混杂因素。
