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SU-E-T-92:关于使用高灵敏度热释光剂量计(TLD)对低能近距离放射治疗源进行剂量学表征

SU-E-T-92: on the Use of High-Sensitivity Thermoluminescent Dosimeters (TLDs) for Dosimetric Characterization of Low-Energy Brachytherapy Sources.

作者信息

Chen Z, Bongiorni P, Donahue W, Hearn R, Rodgers J, Nath R

机构信息

Yale University School of Medicine.

Theragenics Corp, Buford, G A.

出版信息

Med Phys. 2012 Jun;39(6Part11):3723. doi: 10.1118/1.4735149.

Abstract

PURPOSE

To investigate the utility and accuracy of high-sensitivity TLD for dosimetric characterization of low-energy brachytherapy sources.

METHODS

One hundred high-sensitivity (TLD-100H) and 100 normal-sensitivity (TLD-100) TLDs were used in this study. The TLD-100s were annealed at 400°C for one hour and then kept at room temperature for 45 minutes followed by 80°C heating for 24 hours. To prevent temperature overshot from reducing the sensitivity of TLD-100Hs, a novel thermal reservoir was built, tested, and used to anneal TLD-100H at 240 0C for 15 minutes and then kept at room temperature for 45 minutes followed by 100 0C heating for one hour. These TLDs were then irradiated uniformly in a large cavity Cs-137 irradiator for biomedical research (Shepherd, Mark III) to test their reproducibility and to establish their relative sensitivities. The radial dose function of a Model AgX100 125I source was measured using both types of TLDs in water-equivalent solid phantoms as a test case. The radial dose function measured by the TLD-100H was compared with that measured by TLD-100 to determine its utility in brachytherapy dosimetry characterization.

RESULTS

Consistent and accurate annealing of high-sensitivity TLDs was achieved by using a custom-built thermal reservoir system. TLD-100H was found to be about 18 times more sensitive than TLD-100. For a 125I source with a source-strength of 2.7U, the irradiation time for radial dose function characterization up to 7 cm can be cut down from 38 days to 3 days. The radial dose function measured by TLD-100H agreed well (within ±6%) with that measured by TLD-100.

CONCLUSIONS

A novel thermal reservoir was used for consistent annealing of high-sensitivity TLDs. TLD-100H can significantly shorten the irradiation time needed for a complete characterization of radial dose function. Investigation of TLD-100H for complete brachytherapy source characterization is in progress. Supported in part by NIH grant R01-CA134627.

摘要

目的

研究高灵敏度热释光剂量计(TLD)用于低能近距离放射治疗源剂量学表征的实用性和准确性。

方法

本研究使用了100个高灵敏度(TLD - 100H)和100个普通灵敏度(TLD - 100)的TLD。TLD - 100在400°C退火1小时,然后在室温下保持45分钟,接着在80°C加热24小时。为防止温度过冲降低TLD - 100H的灵敏度,构建、测试了一种新型蓄热器,并用于在240°C对TLD - 100H退火15分钟,然后在室温下保持45分钟,接着在100°C加热1小时。然后将这些TLD在用于生物医学研究的大型腔体Cs - 137辐照器(Shepherd,Mark III型)中进行均匀辐照,以测试其重复性并确定其相对灵敏度。作为测试案例,在水等效固体模体中使用这两种类型的TLD测量了AgX100 125I型源的径向剂量函数。将TLD - 100H测量的径向剂量函数与TLD - 100测量的进行比较,以确定其在近距离放射治疗剂量学表征中的实用性。

结果

通过使用定制的蓄热器系统实现了高灵敏度TLD的一致且准确的退火。发现TLD - 100H的灵敏度比TLD - 100高约18倍。对于源强为2.7U的125I源,用于径向剂量函数表征直至7 cm的辐照时间可从38天缩短至3天。TLD - 100H测量的径向剂量函数与TLD - 100测量的结果吻合良好(在±6%以内)。

结论

一种新型蓄热器用于高灵敏度TLD的一致退火。TLD - 100H可显著缩短完整表征径向剂量函数所需的辐照时间。正在对TLD - 100H进行用于完整近距离放射治疗源表征的研究。部分得到美国国立卫生研究院(NIH)资助R01 - CA134627。

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