使用基于猿猴病毒40的穿梭载体分析丝裂霉素C处理的猴细胞中的增强诱变作用。
Use of a simian virus 40-based shuttle vector to analyze enhanced mutagenesis in mitomycin C-treated monkey cells.
作者信息
Roilides E, Munson P J, Levine A S, Dixon K
机构信息
Section on Viruses and Cellular Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
出版信息
Mol Cell Biol. 1988 Sep;8(9):3943-6. doi: 10.1128/mcb.8.9.3943-3946.1988.
Abstract
When monkey cells were treated with mitomycin C 24 h before transfection with UV-irradiated pZ189 (a simian virus 40-based shuttle vector), there was a twofold increase in the frequency of mutations in the supF gene of the vector. These results suggest the existence of an enhancible mutagenesis pathway in mammalian cells. However, DNA sequence analysis of the SupF- mutants suggested no dramatic changes in the mechanisms of mutagenesis due to mitomycin C treatment of the cells.
摘要
在用紫外线照射的pZ189（一种基于猿猴病毒40的穿梭载体）转染前24小时用丝裂霉素C处理猴细胞时，载体的supF基因中的突变频率增加了两倍。这些结果表明哺乳动物细胞中存在一种可增强的诱变途径。然而，对SupF突变体的DNA序列分析表明，由于用丝裂霉素C处理细胞，诱变机制没有显著变化。
相似文献
1
Use of a simian virus 40-based shuttle vector to analyze enhanced mutagenesis in mitomycin C-treated monkey cells.使用基于猿猴病毒40的穿梭载体分析丝裂霉素C处理的猴细胞中的增强诱变作用。
Mol Cell Biol. 1988 Sep;8(9):3943-6. doi: 10.1128/mcb.8.9.3943-3946.1988.
2
Enhanced reactivation and mutagenesis after transfection of carcinogen-treated monkey kidney cells with UV-irradiated simian virus 40 (SV40) DNA.用紫外线照射的猿猴病毒40（SV40）DNA转染经致癌物处理的猴肾细胞后，再激活和诱变增强。
Biochimie. 1982 Aug-Sep;64(8-9):693-6. doi: 10.1016/s0300-9084(82)80112-0.
3
Studies on direct and indirect effects of DNA damage on mutagenesis in monkey cells using an SV40-based shuttle vector.使用基于SV40的穿梭载体对猴细胞中DNA损伤对诱变的直接和间接影响的研究。
Mutat Res. 1989 Mar-May;220(2-3):73-82. doi: 10.1016/0165-1110(89)90012-2.
4
Use of an infectious Simian virus 40-based shuttle vector to analyse UV-induced mutagenesis in monkey cells.使用基于感染性猿猴病毒40的穿梭载体分析紫外线诱导的猴细胞诱变。
Mutat Res. 1996 Dec 2;364(3):235-43. doi: 10.1016/s0921-8777(96)00039-0.
5
Enhanced mutagenesis of UV-irradiated simian virus 40 occurs in mitomycin C-treated host cells only at a low multiplicity of infection.紫外线照射的猿猴病毒40的诱变增强仅在丝裂霉素C处理的宿主细胞中以低感染复数发生。
Mol Cell Biol. 1986 Apr;6(4):1102-7. doi: 10.1128/mcb.6.4.1102-1107.1986.
6
Sequence specificity of point mutations induced during passage of a UV-irradiated shuttle vector plasmid in monkey cells.紫外线照射的穿梭载体质粒在猴细胞传代过程中诱导产生的点突变的序列特异性
Mol Cell Biol. 1986 Jan;6(1):277-85. doi: 10.1128/mcb.6.1.277-285.1986.
7
[Molecular mechanism of mutagenesis induced by aflatoxin B1 using a shuttle vector pSP189/mammalian cell system].[利用穿梭载体pSP189/哺乳动物细胞系统研究黄曲霉毒素B1诱导的诱变分子机制]
Wei Sheng Yan Jiu. 1997 Jul;26(4):271-7.
8
Enhancement of DNA repair capacity of mammalian cells by carcinogen treatment.
Somat Cell Mol Genet. 1988 Jul;14(4):351-7. doi: 10.1007/BF01534643.
9
UV light-induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells.紫外线诱导的环丁烷嘧啶二聚体在哺乳动物细胞中具有致突变性。
Mol Cell Biol. 1986 Oct;6(10):3349-56. doi: 10.1128/mcb.6.10.3349-3356.1986.
10
Evidence for nontargeted mutagenesis in a monkey kidney cell line and analysis of its sequence specificity using a shuttle-vector plasmid.猴肾细胞系中非靶向诱变的证据及其使用穿梭载体质粒的序列特异性分析。
Mutat Res. 1994 Mar;323(3):105-12. doi: 10.1016/0165-7992(94)90083-3.
引用本文的文献
1
Stress response induced by DNA damage leads to specific, delayed and untargeted mutations.DNA损伤引发的应激反应会导致特定、延迟且无靶向性的突变。
Mol Gen Genet. 1992 Aug;234(2):217-27. doi: 10.1007/BF00283842.
本文引用的文献
1
The SOS regulatory system of Escherichia coli.大肠杆菌的SOS调控系统。
Cell. 1982 May;29(1):11-22. doi: 10.1016/0092-8674(82)90085-x.
2
Indirect induction of mutagenesis of intact parvovirus H-1 in mammalian cells treated with UV light or with UV-irradiated H-1 or simian virus 40.在用紫外线、紫外线照射的H-1或猿猴病毒40处理的哺乳动物细胞中，完整细小病毒H-1诱变的间接诱导。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4480-4. doi: 10.1073/pnas.78.7.4480.
3
Mechanisms of DNA replication and mutagenesis in ultraviolet-irradiated bacteria and mammalian cells.紫外线照射的细菌和哺乳动物细胞中DNA复制及诱变的机制
Prog Nucleic Acid Res Mol Biol. 1981;25:53-126. doi: 10.1016/s0079-6603(08)60483-3.
4
Carcinogens induce targeted mutations in Escherichia coli.致癌物可在大肠杆菌中诱发靶向突变。
Cell. 1982 Nov;31(1):5-7. doi: 10.1016/0092-8674(82)90398-1.
5
Is there SOS induction in mammalian cells?哺乳动物细胞中存在SOS诱导吗？
Photochem Photobiol. 1980 Dec;32(6):823-30. doi: 10.1111/j.1751-1097.1980.tb04062.x.
6
Specificity of mutagenesis resulting from the induction of the SOS system in the absence of mutagenic treatment.在无诱变处理情况下，SOS系统诱导所产生诱变的特异性。
Cell. 1984 Jun;37(2):675-82. doi: 10.1016/0092-8674(84)90400-8.
7
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.大肠杆菌中的诱变作用及对脱氧核糖核酸损伤的诱导反应
Microbiol Rev. 1984 Mar;48(1):60-93. doi: 10.1128/mr.48.1.60-93.1984.
8
The role of pyrimidine dimers as premutagenic lesions: a study of targeted vs. untargeted mutagenesis in the lacI gene of Escherichia coli.嘧啶二聚体作为前诱变损伤的作用：大肠杆菌lacI基因中靶向诱变与非靶向诱变的研究。
Genetics. 1984 Mar;106(3):347-64. doi: 10.1093/genetics/106.3.347.
9
Mutagenesis of a shuttle vector plasmid in mammalian cells.穿梭载体质粒在哺乳动物细胞中的诱变
Mol Cell Biol. 1984 Mar;4(3):435-41. doi: 10.1128/mcb.4.3.435-441.1984.
10
Further evidence that ultraviolet radiation-enhanced reactivation of simian virus 40 in monkey kidney cells is not accompanied by mutagenesis.进一步的证据表明，紫外线辐射增强猴肾细胞中猿猴病毒40的复活并不伴随着诱变作用。
Mutat Res. 1982 Nov;105(5):291-8. doi: 10.1016/0165-7992(82)90095-1.
Zotero 插件