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在用紫外线、紫外线照射的H-1或猿猴病毒40处理的哺乳动物细胞中,完整细小病毒H-1诱变的间接诱导。

Indirect induction of mutagenesis of intact parvovirus H-1 in mammalian cells treated with UV light or with UV-irradiated H-1 or simian virus 40.

作者信息

Cornelis J J, Su Z Z, Ward D C, Rommelaere J

出版信息

Proc Natl Acad Sci U S A. 1981 Jul;78(7):4480-4. doi: 10.1073/pnas.78.7.4480.

Abstract

The frequency of mutants among the descendants of intact parvovirus H-1 was increased when cells of human and rat origin were exposed to UV light prior to infection. An enhanced mutagenesis of intact H-1 could be induced to almost the same extent in unirradiated cells by preinfecting them with H-1 or simian virus 40 that had been irradiated with UV light. The expression of an enhanced mutagenesis of unirradiated H-1 after cell treatment with UV light or UV-irradiated virus was delayed, transient, and dose-dependent, and it was dependent on de novo protein synthesis.

摘要

当人和大鼠来源的细胞在感染前暴露于紫外线下时,完整细小病毒H-1后代中突变体的频率会增加。通过用紫外线照射过的H-1或猿猴病毒40预感染未照射的细胞,完整H-1的诱变增强几乎可以达到相同程度。在用紫外线或紫外线照射过的病毒处理细胞后,未照射的H-1诱变增强的表达是延迟的、短暂的且剂量依赖性的,并且它依赖于从头合成蛋白质。

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Indirect ultraviolet-reactivation of phage lambda.噬菌体λ的间接紫外线复活作用。
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