过氧化物酶催化硫醇的过氧化物酶-氧化酶氧化的能力。
Abilities of peroxidases to catalyse peroxidase-oxidase oxidation of thiols.
作者信息
Svensson B E
机构信息
Research and Development Laboratories, Astra Alab AB, Södertälje, Sweden.
出版信息
Biochem J. 1988 Dec 15;256(3):757-62. doi: 10.1042/bj2560757.
Abstract
The abilities of various peroxidases to catalyse the peroxidase-oxidase oxidation of seven aminothiols were studied. Cysteamine and cysteine esters were found to be peroxidase-oxidase substrates for eosinophil peroxidase and myeloperoxidase, whereas other thiols tested were inactive or poorly active with these peroxidases. With lactoperoxidase and horseradish peroxidase, all the tested thiols were inactive or poorly active as peroxidase-oxidase substrates. These studies suggest that a main reason for thiols being poor peroxidase-oxidase substrates is because these thiols are poor peroxidatic substrates.
摘要
研究了各种过氧化物酶催化七种氨基硫醇的过氧化物酶-氧化酶氧化反应的能力。发现半胱胺和半胱氨酸酯是嗜酸性粒细胞过氧化物酶和髓过氧化物酶的过氧化物酶-氧化酶底物，而测试的其他硫醇对这些过氧化物酶无活性或活性较差。对于乳过氧化物酶和辣根过氧化物酶，所有测试的硫醇作为过氧化物酶-氧化酶底物均无活性或活性较差。这些研究表明，硫醇作为过氧化物酶-氧化酶底物活性较差的主要原因是这些硫醇是较差的过氧化物底物。
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本文引用的文献
1
THE MECHANISM OF AEROBIC OXIDASE REACTION CATALYZED BY PEROXIDASE.过氧化物酶催化的需氧氧化酶反应机制
Biochim Biophys Acta. 1963 Sep 3;77:47-64. doi: 10.1016/0006-3002(63)90468-2.
2
Mechanisms of oxygen metabolism.氧代谢机制
Adv Enzymol Relat Subj Biochem. 1957;19:79-233. doi: 10.1002/9780470122648.ch2.
3
The isolation and purification of lactoperoxidase by ion exchange chromatography.通过离子交换色谱法分离和纯化乳过氧化物酶。
J Biol Chem. 1957 Oct;228(2):767-76.
4
Free radical metabolites of L-cysteine oxidation.L-半胱氨酸氧化的自由基代谢产物。
J Biol Chem. 1984 May 10;259(9):5606-11.
5
Some properties of human eosinophil peroxidase, a comparison with other peroxidases.人嗜酸性粒细胞过氧化物酶的一些特性，与其他过氧化物酶的比较。
Biochim Biophys Acta. 1984 Jan 31;784(2-3):177-86. doi: 10.1016/0167-4838(84)90125-0.
6
Mechanism of halide-stimulated activity of chloroperoxidase evidence for enzymatic formation of free hypohalous acid.卤化物刺激氯过氧化物酶活性的机制：游离次卤酸酶促形成的证据
Biochem Biophys Res Commun. 1983 Nov 15;116(3):873-9. doi: 10.1016/s0006-291x(83)80223-x.
7
Oxidation of indole-3-acetic acid by peroxidase: involvement of reduced peroxidase and compound III with superoxide as a product.过氧化物酶对吲哚 - 3 - 乙酸的氧化作用：还原型过氧化物酶和化合物III的参与以及超氧化物作为产物的生成
Biochemistry. 1982 Aug 31;21(18):4414-9. doi: 10.1021/bi00261a034.
8
Oxidation of glutathione by the myeloperoxidase system.谷胱甘肽被髓过氧化物酶系统氧化。
J Reticuloendothel Soc. 1982 Apr;31(4):353-60.
9
Human eosinophil peroxidase: a novel isolation procedure, spectral properties and chlorinating activity.人嗜酸性粒细胞过氧化物酶：一种新的分离方法、光谱特性及氯化活性。
FEBS Lett. 1981 Jan 26;123(2):327-31. doi: 10.1016/0014-5793(81)80320-1.
10
The reductive cleavage of myeloperoxidase in half, producing enzymically active hemi-myeloperoxidase.髓过氧化物酶还原裂解为两半，产生具有酶活性的半髓过氧化物酶。
J Biol Chem. 1981 May 10;256(9):4211-8.
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