Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Departments of Child and Adolescent Psychiatry and.
Pain. 2017 Aug;158(8):1554-1560. doi: 10.1097/j.pain.0000000000000950.
The aim of this study was to examine a possible relationship between early puberty and chronic nonspecific pain in 13- to 18-year-old girls. All adolescents in Nord-Trøndelag County, Norway, were invited to participate in the Young-HUNT3 study (2006-2008). Of the invited girls, 81% answered the questionnaire and of these 3982 were 13 to 18 years of age. Menarche and perceived physical maturation were used as exposure measures. Early menarche was defined as <12 years, normal menarche as ≥12 and <14 years, and late menarche as ≥14 years. Perceived physical maturation was divided into maturing earlier, the same or later than others of their own age. The main outcome measure was chronic nonspecific pain, defined as pain in at least one location not related to any known disease or injury, for at least once a week during the last 3 months. The median age at menarche was 13.2 years. Chronic nonspecific pain was more prevalent among girls with early menarche (68%, 95% CI: 64%-72%) compared to girls with either normal (55%, 95% CI: 53%-57%), late (50%, 95% CI: 46%-54%), or no menarche (35%, 95% CI: 29%-40%). The association persisted after adjusting for age, body mass index, socioeconomic factors, and anxiety and depression. A similar association was found between girls that perceived themselves as earlier physically matured than their peers and chronic nonspecific pain. Headache/migraine was the most common type of chronic nonspecific pain regardless of menarcheal age. In all reported locations, pain was more prevalent in the group with early menarche compared to normal or late menarche.
本研究旨在探讨 13 至 18 岁女孩青春期提前与慢性非特异性疼痛之间的可能关系。挪威特隆赫姆郡的所有青少年都被邀请参加 Young-HUNT3 研究（2006-2008 年）。在受邀的女孩中，81%回答了问卷，其中 3982 人年龄在 13 至 18 岁之间。初潮和感知的身体成熟度被用作暴露测量指标。初潮提前定义为<12 岁，正常初潮定义为≥12 岁且<14 岁，晚初潮定义为≥14 岁。感知的身体成熟度分为早成熟、与同龄人相同或晚成熟。主要结局指标是慢性非特异性疼痛，定义为至少有一处与任何已知疾病或损伤无关的疼痛，在过去 3 个月中至少每周出现一次。初潮的中位数年龄为 13.2 岁。与正常初潮（55%，95%CI：53%-57%）或晚初潮（50%，95%CI：46%-54%）的女孩相比，初潮提前的女孩（68%，95%CI：64%-72%）更易发生慢性非特异性疼痛。在调整年龄、体重指数、社会经济因素以及焦虑和抑郁状况后，这种关联仍然存在。那些认为自己比同龄人更早成熟的女孩与慢性非特异性疼痛也存在类似的关联。无论初潮年龄如何，头痛/偏头痛都是最常见的慢性非特异性疼痛类型。在所有报告的部位，初潮提前组的疼痛发生率均高于正常或晚初潮组。
