人类免疫缺陷病毒（HIV）治愈的观点：HIV在组织中的持续存在
Perspectives on Human Immunodeficiency Virus (HIV) Cure: HIV Persistence in Tissue.
作者信息
Boritz Eli A, Douek Daniel C
机构信息
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
出版信息
J Infect Dis. 2017 Mar 15;215(suppl_3):S128-S133. doi: 10.1093/infdis/jix005.
Abstract
The uneven anatomic distribution of cell subsets that harbor human immunodeficiency virus (HIV) during antiretroviral therapy (ART) complicates investigation of the barriers to HIV cure. Here we propose that while previous studies done largely in blood cells have led to important investigations into HIV latency, other important mechanisms of HIV persistence during ART may not be readily apparent in the bloodstream. We specifically consider as an example the question of ongoing HIV replication during ART. We discuss how growing understanding of key anatomic sanctuaries for the virus can inform future experiments aimed at further clarifying this issue.
摘要
在抗逆转录病毒疗法（ART）期间，携带人类免疫缺陷病毒（HIV）的细胞亚群在解剖学上分布不均，这使得对HIV治愈障碍的研究变得复杂。我们认为，虽然之前主要在血细胞中进行的研究对HIV潜伏期进行了重要调查，但在ART期间HIV持续存在的其他重要机制在血液中可能并不明显。我们特别以ART期间HIV持续复制的问题为例进行探讨。我们讨论了对病毒关键解剖学庇护所的日益深入的理解如何为未来旨在进一步阐明这一问题的实验提供信息。
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